Flu jab and methotrexate

[Uga35570]

The only day I could get an appointment for flu is Tuesday 26th. I have 25mgs methotrexate weekly by injection each Tuesday anyone know if this is a problem to have both on the same day.

[Neonkittie17]

There has been research that Mtx can for some people blunt the efficacy of the flu and pneumonia vax. You may need to leave a gap between your Mtx and having had the flu vaccine. I’d ask your rheumy their advice.

[Gottaloveastaffy]

Hey. I’m due a flu jab and my rheumy says prob best not to have methotrexate the same day xx but you should go on the advice of your own rheumy xx

[nomoreheels]

This isn’t about flu jab & MTX on the same day but there have been multi-centre, randomized, parallel-group trials (on different years) which show withholding MTX for 2 weeks after having the flu jab improves it's efficacy. Around 75% of those who did had a better response as opposed to an average of 55% who continued their MTX as normal. The response didn't differ between patients who received the flu jab within 3 days of the last MTX dose & those who received it between 4-7 days of the last MTX dose. These findings were considered to have less substantial impact on disease activity (withholding MTX for 2 weeks) as opposed to the previous 4 week withdrawal trials. It does conclude that this evidence isn't supported in current guidelines, so it's down to our Rheumy's thoughts & preferences for their patients on an individual basis.

Just thought it was interesting.

[Lyndylou34]

Hi, my Covid and flu jabs were booked for the same day as my Methotrexate day. I was told to miss that week.

[bienassis]

I was told that some doctors advise a week's separation and others say it makes no difference if the two are on the same day. So nothing new there!

I decided to err on the cautious side, but that was my choice. Rheumy nurse said most will do the same. Their choice.