Just enquiringly how long oral methotrexate should take to work.im on my 8th wk of taking it.starting at 7.5mg and now up to12.5mg.will be at 15mg come Monday.i also take 3mg(6tabs) of sulfasalazine daily too.this initially worked on its own but methotrexate was added when it stopped working.knees still very sore stiff and swollen.ankles and feet just really sore.
No marked improvement after 7weeks: Just enquiringly... - NRAS
Unfortunately, finding what works can be quite brutal. Mtx may not work in the end by itself. I was told that each DMARD is tested for a minimum of 3 months before adding something else if it doesn’t work. I took oral steroids for over 2 years to support 20mg mtx, sulfasalazine. Already given up on hydroxy as was pointless. At 2 and a half years and finally off steroids, was almost immobile still, so approved for Benepali. I’m now in a very different place.
That’s probably not what you really want to hear, and I hate that due to funding mainly, all the cheaper stuff is tried first when biologics appear to help immensely. Steroids will mask the disease to some extent which is not always a good thing.
I hope you find what works for you very soon. It’s horrid feeling so rubbish all of the time.
Hi. Stick with it, the impact from the MTX takes about 3 months to kick in. My rheumatologist gave me a steroid injection to ease the pain in the meantime. Maybe worth ringing your rheumatoid helpline in the hospital and explain your pain and hopefully they too will offer you a steroid injection 🤞🏻.
Started almost a year ago. Building the dose each time I visited the doc three months apart and new bloods drawn. I’m at 25 MG. splitting the dose 5 tabs one day and 5 tabs the next. I’m ok most of the time but pain can hit me anywhere making me either miserable or just uncomfortable. Right now my jaw is bothering me and may go to dentist to check it out. Last week it was my chest. Prednisone when there’s a flare. Hate it. Good luck with yours.
I've been on 10mg, then 15mg MTX total of 8 weeks. However, weaning off Prednisone too. It is hard to tell if the MTX is working because the Pred. works very well for me for pain. I'm going from 15mg Pred. to 10mg. tomorrow. Then after a month, nothing I think. The MTX is supposed to have taken over the job. My Internist is working my meds. and I think it takes a LONG time to get it right. Pain is surely the hallmark of RA. Hope my limited info is helpful.
I would have thought it would have been better for me to stay on the prednisalone for more than 4wks,at least enough time for slight improvement,but this wasn’t to be.im sure my rhuemo nurse had a reason for this.so from all the comments i’m just going to have to put up with the pain and wiped out feeling a bit longer to see if adding the max is going to make a difference.thanks everyone for replying.