I’ve been taken off methotrexate: I’ve recently been... - NRAS

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I’ve been taken off methotrexate

LyndaKenny profile image
6 Replies

I’ve recently been taken off methotrexate due to high liver readings. I’m now taking leflunomide and plaquenol

Since the switch I’ve flared up and in agony every day. Does anyone know how long these new drugs take to work?

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LyndaKenny profile image
LyndaKenny
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6 Replies
oldtimer profile image
oldtimer

Most people seem to respond in 3 to 6 months, occasionally more quickly. Can you have steroids (injection or tablets) to cover you while you make the switch?

LyndaKenny profile image
LyndaKenny in reply tooldtimer

I’m already on them too

sharon6768 profile image
sharon6768 in reply tooldtimer

Really, 3 to 6 months? Oh crap! Off to the pain clinic for injections.

sharon6768 profile image
sharon6768

Lynda, I have been on 20mgs of leflunomide for a month now and, so far, no improvement. I know it takes awhile, but I am very frustrated.

LyndaKenny profile image
LyndaKenny in reply tosharon6768

I get you I really do

sharon6768 profile image
sharon6768 in reply toLyndaKenny

Lynda, it's now been about 8 weeks on lef and I now have a lot less pain. Yahoo! I can only hope it continues.

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