Insomnia with methotrexate : Hi, Lately I’ve been... - NRAS

NRAS

37,230 members46,078 posts

Insomnia with methotrexate

Exhaustednpained profile image
9 Replies

Hi, Lately I’ve been having extreme insomnia where I’ll lie awake all night tossing, reading, and am only able to fall asleep late in the morning like at 4 and 5 mostly. I’ve been getting 2-3 hours of sleep a night and I feel exhausted all day. This became a lot worse when I began my dose of methotrexate again. What can I do to counter these effects and does anyone know if methotrexate worsens insomnia?

Written by
Exhaustednpained profile image
Exhaustednpained
To view profiles and participate in discussions please or .
Read more about...
9 Replies
crashdoll profile image
crashdoll

I’m sorry you’re struggling with insomnia, it’s the worst. :( What time of day do you take the MTX? I found humira gave me insomnia if I injected at night, so I switched to first thing in the morning and it improved hugely. Are you on anything else that could be contributing to the insomnia?

Exhaustednpained profile image
Exhaustednpained in reply tocrashdoll

I’m on so much which probably could be suspect! Let’s c: Actemra, nabumetone, amitriptyline, tropiramate, and several steroid eye drops. I usually take methotrexate at night, which may be the cause...

Lyneal profile image
Lyneal

Hi, I have had same sleep problems on MXT, been off MXT for two week as getting eye infections, have slep great not on it. So that tells us something.

Exhaustednpained profile image
Exhaustednpained in reply toLyneal

Yes, thank you... hearing other people have felt like this too is idk, validating?

Similar, slept much better since off MTX ( well apart from last night but waffled on enough about that already😊). I’m still not sure whether drugs or disease: at least you’ve got someone to talk to in early hours on here - sleeplessness seems issue for loads 😉

nomoreheels profile image
nomoreheels

As you're taking your MTX at night it could be related to your insomnia I suppose. I'd experiment with the time of day you take it. You don't say whether it's tablets or injections but I inject MTX in the morning. If it's tablets, again you could try mornings or even as I did, throughout the day with meals. If there's no improvement try the same with your other meds, except the tropiramate of course & your nabumetone if you take that in the evening.

Just wondering, when do you take your amitriptyline? I also take it, 25mg in the morning & 50mg in the evening, the latter helps me sleep, wondering if it could you too.

If none of above help maybe look at what you're doing before you go to bed. Such as are you affected by caffeine, not relaxing generally & other common causes of insomnia.

I hope you get to the bottom of it, I've been there & it's rubbish.

Maggsie profile image
Maggsie

I used to take mine just before bed and always struggled with sleep for a few hours. Tried switching to mornings but felt rubbish all day. Now take at about 6pm and am ready for sleep about 10, then crash til morning. Not so bad the next day either.

Exhaustednpained profile image
Exhaustednpained in reply toMaggsie

Thank you!

Rummi profile image
Rummi

Just started 4 weeks ago...take mine on a monday morning...effects for me are headaches..

tiredness ...and insomnia...does this get better with time

Not what you're looking for?

You may also like...

Insomnia methotrexate?

Morning all I just wondered about insomnia with methotrexate. I had what I thought was insomnia on...
Shazz10 profile image

Severe insomnia and limited meds to take while on Hydroxy.

Hi all, first timer on this thread. I’ve been on Plaquenil for 5-years to treat RA and also on...
Mialuke profile image

Methotrexate

I’m going to the rheumy today to be started on methotrexate (but will only be starting it on...
Hels1989 profile image

Methotrexate ???

Hi all. I’ve been on methotrexate for 6 years now. Started with 25m oral,have slowly reduced it...
mickyb profile image

Methotrexate jabs

I’ve been taking methotrexate injections for many years with no side effects. But for several...
Junny123 profile image

Moderation team

See all
KateL-NRAS profile image
KateL-NRASAdministrator
Donagh-NRAS profile image
Donagh-NRASAdministrator
Nicola-NRAS profile image
Nicola-NRASAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.