Hi everyone - I'm new to the forum but have been a member of NRAS for 15years. Diagnosed with RA in 2000 when the most popular treatment was the cocktail of Methotrexate, Sulfasalazine and Hydroxy..... I have to say they worked really well in keeping the flare ups at bay but the fatigue was the pits. The last five years have been the worst though after having shingles and for some reason I now have three days of nausea after my methotrexate - give me the fatigue any day!! RA is also a condition that leaves me feeling quite isolated on some days - people automatically assume that I won't be able to do a certain activity so I don't get invited!! In fact I can do all sorts on any one day knowing that I will feel as if I have been hit by a bus the next day so I plan my activities accordingly and life goes on - never say never!