I have been on this medication before and my rhumey wanted me to try it again along with the Tocizumab infusions/injections. I have the same side effects where it effects my bowels. It is if I have lost control, they become very soft and it can be embarrassing as I can sometimes not make it to the bathroom in time. I sawait my GP and she put me on imodium but said only to take an half hour before going out due to all the other medications. I said it is ad if I have IBS but she couldn't give me anything for that. I would appreciate if anyone has anything like this. I understand it isn't a nice subject to discuss. I have had bowel cancer testing done over a year ago and they have come back clear. I have noticed several messages on here and it has made me wonder if I need to be retested. I see my GP next week and my Rheumatologist the following week.