Just wanted to share my experience for anyone that is about to start on Rituximab...I had my first infusions in April, 2 weeks apart and felt so ill for 2 weeks after each one. Seemed to have pain in every joint in my body. I struggled through May and June with no signs of improvement at all. At the end of June, I cried in my rheumatologists office when she asked me how I was. I was literally on my knees. She and my wonderful nurse said hang in there, it will kick in. Don't give up. I had a steroid injection to help. Then the 2nd week in August, I realised that I had had 4 late nights in a row and I was still functioning and not in awful pain. 4 days turned into 2 weeks and then into 6 weeks. I still have some swelling but not the relentless pain. I was so excited that I decided to paint all the rooms in the downstairs of my house! May have overdone it slightly my shoulder and hands were not amused but in general I felt on top of the world. Saw my nurse today and my bloods are showing this improvement too. I am scheduled for next infusions at the end of October. I just wanted to tell anyone who was where I was 3 months ago - not to give up and it might work for you like it seems to be for me My consultant and specialist nurse are 2 of the most amazing people and I am so grateful for having them both help me through this nightmare of a 3 year journey.