Hi--- I'm at the start of my third week of meds- 200 mg of hydrox and 15 mgs of Mtx, 5mg of f acid(once a week). After spending the first night with my head down the toilet I rang my gp who gave me anti sickness pills to take 3 times daily-- since taking those I just have permanent but slight nausea. My watch and rings are looser but the pain in my hands is still excruciating. I realise that after reading the posts on here that I appear to have so far escaped lightly re side effects( for which I am so grateful) but am just wondering if anyone can help with my question. My specialist says to take 8 co codamol daily along with 1800 mg of ibruphen--- but my local chemist, who is usually brilliant, says its not a good idea to mix mtx with anti inflams even tho Itake 60 mil of lanzoprozole. Thanks.