After thinking I may have RD for over a year, it was finally confirmed yesterday. I did see a locum rheumie last year but I think there was a mix up as the consultant yesterday asked why I'd never had a follow up appointment. Anyway, that's irrelevant now. I'm being started on DMARD combination therapy in 6 weeks (because I'm going on holiday soon and the rheumie said not to start them unless I was prepared to take him on hoiday too!). I got a steroid injection to tide me over meantime. What I wanted to ask is what day should I take the methotrexate tablets (15mg) on? I work 4 days a week and I don't want to have to take more time off than I have to if I have side effects. If I take them on a Saturday, will that be my weekend wiped out? When do the side effects generally kick in? Thanks!