I've been told to come off mtx for two weeks due to the side effects and then slowly come back on it and possibly try a different treatment if the side effects persist. I'm at the end of my two week break and due to start up again tomorrow. During these last two weeks, though, I've been getting almost daily headaches and the occasional migraine. I don't normally get migraines (or even headaches this frequently) so the only thing I can put it down to is coming off mtx but I don't know if two weeks is even long enough to experience withdrawal or if mtx even causes this. Has anyone experienced this before?