Why can't you drink while taking methatraxate? - NRAS

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Why can't you drink while taking methatraxate?

Laceygreen profile image
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Laceygreen profile image
Laceygreen
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17 Replies

As I understand it, methotrexate is hard on the liver, so is alcohol, therefore combining the two greatly increases the risk of liver damage. A lot of people do drink a bit while on mtx but I doubt very much that anyone really gets away with heavy drinking.

After a few months on mtx the regular blood tests showed my liver levels to be fine so I tentatively started having a couple of glasses of wine a week. Liver results remained fine so occasionally I'd drink a bit more than that but my days of getting completely blotto are over. Life without hangovers is lovely. Shame about the flipping illness though.

Like postle said its hard on the liver. My rheumatologist said I could have three drinks a month not two at a time, one at a time only. Your rheumatologist knows best, you should really ask her. Everybody's different, the amount of medication is different. Now I don't think I can drink, all because my doctor added Enbril. I will have to ask my rheumatologist next time I see her. I drink once in a while would be nice!

Mutleymutley profile image
Mutleymutley

I have been on Mtxate for 2 years and regularly drink rose wine, I was told I could drink, but in moderation! I enjoy my glass or two of wine at the end of a day at work and obviously if my blood tests showed any issues I would stop.

cathie profile image
cathie

I stopped drinking - not that I drank a lot- and still got liver damage on mtx. But it helped my ra

norfolkjo profile image
norfolkjo

Because the fun police say so ...

Seriously its as the others said

I became a heavy drinker when first diagnosed ( four ot fivr bottless of wine a week.. mainly to painkill and make me sleep) I worried I wouldn't cope so I started buying non alcohol wine and two bottles of 5 percent wine making a weekly unit of 8 a week . I have nothing either side and meths day . I used the non alcohol as a crutch bit like an e ciigarette. Drunk from wine glass. In six weeks I am now down to one bottle and cups of tea. This week on holidays I had a small glass of normal wine and felt drunk so my tolerance is now so low that low alcohol now give me that arrgh feeling. If my liver tests wobble its an easy decision to cut out completely as I feel so much better on meths its worth it

nomoreheels profile image
nomoreheels in reply tonorfolkjo

Hiya norfolkjo. I wouldn't advise drinking meths (5th line)!!!! Seriously though glad to hear you've more or less knocked the alcohol on the head, it's not worth it. I don't drink as it doesn't like me & also have a low tolerance. I was upped to 20ml methotrexate for 3 months & had to come back down to 15ml because my liver function test results went daft. Not tried it myself cos I'm not that bothered about wine but I believe Sainsbury's red grape juice (in the wine isle) is acceptable.

Hope your next results are there or thereabouts so you know just what your liver is happy with!

cathie profile image
cathie in reply tonomoreheels

If you've a wait rose near you they do a lovely 1% alcohol cider - not advertising I hope

Hi

Many a consultant has said it is fine to have the occasional drink with MTX so as others have said here in moderation should be fine but probably best to wait until you've been on MTX for a little while and had your blood tests regularly to ensure nothing going on with your liver. There are some really useful video clips on the nras website by people talking about taking MTX which you may find helpful.nras.org.uk/about_rheumatoi...

jeanjack profile image
jeanjack

I too love a glass of wine and was doing okay with my Methotrexate and drinking a couple of small glasses on a Friday and Saturday night. I then went on holiday and thought " who cares, I'm on holiday, I'm going to enjoy myself " I had wine every evening for a week and thoroughly enjoyed it but when I came back and had a blood test my ALT levels had jumped from 21 to 95. Rheumy did another test and said it showed the rise was directly linked to alcohol. Needless to say I have cut it right back now and have discovered Sainsbury's 1% cider which is very nice. My latest blood test shows ALT back down to 22 so it just shows you can't mess about with MTX.

I think it's because alcohol increases the toxicity of the Methotrexate. For some it's time to become teetotal while others seem to tolerate a few units of alcohol okay. I find can't drink at all or it shows up in my blood results.

Twitchy

angel-delight profile image
angel-delight

Hello, I was advised that I could have a drink now and again but not the day before or after. I am no longer on MTX due to the side effects, the following day I would be really sick and spent most of the day in the bathroom, even if I didn't have a drink. I never drink wine of any kind as I felt worse the next day. My joints flared up and I was told it is like some foods with acid content, like apples, oranges etc, so I just leave them out of my list of foods I can eat. I don't miss out at all as I was a drinker, more a social drinker, special occassions only. I still had a good time. Hope you are not suffering too much and enjoying the Easter holiday. xx

nomoreheels profile image
nomoreheels in reply toangel-delight

It appears there is so much conflicting advice given by the medical profession. My Consultant in Spain said it was ok to drink wine & beer in moderation except on the day of taking methotrexate. His only real no no were spirits (hard drink as he put it)! Don't drink anyway so didn't apply to me luckily. Make up for it in choc & cakes!! Luckily don't have to watch my weight.

norfolkjo profile image
norfolkjo

It's a fine line

Koppaburg do a mixed fruits no alc cider and I swear it tastes the same. But as nomoreheels says . I drink meths so I am beyond help snigger xxx

norfolkjo profile image
norfolkjo

Just watched those videos really good x

DrWhoFan profile image
DrWhoFan

When I was on Mtx my rheumy team told me I could drink. I used to have 3 x 125ml glasses of wine a night. No adverse effects, bloods normal. Go for it! Anne

Scottishlad profile image
Scottishlad

I think it is important to avoid alcohol when you start methotrexate. Some people have strong liver reaction as soon as they begin taking methotrexate. If your tests come back okay then moderate alcohol consumption should be okay after you reach the dose which works for you.

I would always suggest a cautious approach to alcohol and methotrexate.

Cecil

L1zzy profile image
L1zzy

I was told not to drink alcohol when taking Mtx as both substances are harmful to the liver. Obviously if you combine the two, you risk double the trouble. I used to drink quite a lot, I stopped and don't miss it. Although, at Christmas a few years back, I did have a couple of glasses of wine and some port, and it showed up in my blood tests. I had to come off of Mtx for a month or so until liver results were back to normal... so not worth it.

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