I started methotrexate by injection 2 weeks ago on a Friday and seem to spend most of the time in between recovering from the injection. Is it possible to delay the injection by 2 days as we are currently on holiday in Spain and my family are anxious for me to enjoy myself and not spend the last two days in bed with a difficult journey back like our arrival? I have tried to contact the rheumatology nurses to no avail. Has anyone got any advice for me? In any event I would like to change the day I inject to a Monday if I am going to be tough afterwards as I work at weekends.