Another success?

[FThomp]

I remember reading an article posted here about this surgery being done and apparently it’s been done a second time and was also successful. Just thought I would share some good news with everyone. There’s still work to be done but the future looks bright and positive!

nyulangone.org/news/nyu-lan...

[Sophiebun11]

Science is truly amazing.

[FThomp in reply to Sophiebun11]

I agree. Each step is closer to a more fulfilling life for many who are hampered by ckd. Eventually it could be as trivial as something like appendix removal or something.

[Marvin8]

THANKS for the update!!! I wonder why they didn't let the kidney work past the same 54 hour period as the first trial.

[FThomp in reply to Marvin8]

You’re welcome! If I had to guess it’s probably a regulatory or ethics thing that’s restricting how long they can experiment on a person who’s brain dead but their body is still technically alive?

[Marvin8 in reply to FThomp]

I'm guessing you're probably right. Then again, there may be a scheduling conflict with the surgeon's golf game.

[NilsB]

Thank you for sharing this. I had heard of the first transplant and a second successful one (to date) is wonderful news.

[FThomp in reply to NilsB]

Of course! I’d be curious to know if they had to use any immunosuppressants or if they were able to forego them since they genetically engineered the kidney to not include the gene that causes the acute rejection. If I remember correctly they also implanted the pigs thalmus or thyroid or whatever to help the body repcgnize the organ as it’s own and not foreign

[NilsB]

Implanting a thalamus seems impossible and a thyroid... I would have to read up on that, but if they have removed the gene that causes rejection, additional measures to 'trick the brain' would seem superfluous. If you have more info on that, send a link and I'll definitely go over it,

[FThomp in reply to NilsB]

Hey Nils, sorry I misspoke. There was some talk about possibly using the “thymus” to help with rejection. I thought that had actually implanted it but was just a hypothetical situation in this link. Hopefully we can just genetically engineer organs to never be recognized as foreign to altogether.

google.com/amp/s/www.scienc...

[Sophiebun11 in reply to FThomp]

That would be the ideal situation. Something the body doesn't recognize as a foreign object. Transplanted organs cause a reaction much like those of us with autoimmune diseases have within our own bodies attacking parts that we were born with and actually belong inside of us.

I suppose there is a lot to work out before it's tried on a live human. I don't doubt that it will be before long. Kidneys were the first organs ever transplanted back in 1954; way before heart or lung transplants became routine in the late 60 and 80s respectively.

[FThomp in reply to Sophiebun11]

I like your positive outlook! It does seem like kidneys as advanced as the are seem to be the more more plausible organ for near future innovation compared to others.

[Tony_Mimicted]

I really hope this becomes a reality because not only would this boost kidney organs needs, it can also pave the path for other organ transplants

[FThomp in reply to Tony_Mimicted]

I agree. It would be a watershed moment in the transplant field