Lowering of uremic toxins

[vinadhun2]

has anyone tried Kremezin or Renadyl to lower uremic toxins?

Do these drugs really work as the concept is different

[Helloyall]

What uremic toxins specifically? That's what dialysis does

[vinadhun2 in reply to Helloyall]

Creatinine, Uric acid , Urea etc.,

I am talking about using the mentioned drugs mainly for pre dialysis patients specially in stage 3 and 4

[Helloyall in reply to vinadhun2]

Best thing you can do is diet and limit salt

[Helloyall in reply to vinadhun2]

I have no personally used it but it appears effacuous and should be a tool too halt progression. Downside on the first it is potentially constapat8ng. You are not on fluid restrictions yet so drink a lot of water Stay on restricted renal diet too.

[orangecity41 NKF Ambassador]

I was prescribed Allopurinol (a gout medicine) for hyperuremia and so far is working. I have not had experience with Renadyl nor Kremezin.

[HealthBuddyMelissa]

To my knowledge they are very expensive. I personally would try major diet changes first, and then if there is no success there, then move to the medicines if doctor recommends.

[DadviceTV]

My doctor recommended Renadyl once I got as far as diet could take me (from GFR 8 to GFR 29). For months I was stuck in the same place, my diet hit a wall. I got labs, took Renadyl for 3 months while still dieting (but I wasn’t super great at sticking to my diet at that time), then got labs again, My creatinine dropped from 2.52 to 2.25 and BUN dropped to almost normal. My GFR increased to 33 and I continue to take it (I do not have more recent labs).

I am a supporter of adding Renadyl (not a drug, but a probiotic) to a persons treatment strategy. Many renal dietitians also utilize it ALONG with diet for CKD patients. Make sure your diet is on track - it won’t make up for a bad diet, but has the potential to help along with a good diet. I recommend doing what I did, get labs, take it for 90 days, get new labs. Then you will know if it is worth it for you. It cost almost $2 a day, so you should have labs to support using it long term.

I have several videos about it posted online, including interviews with renal dietitians and my before and after labs. The science behind Renadyl is sound, but our bodies and gut health are all a bit different. For me, it is the first thing from a bottle that actually made a significant difference in my labs. Everything else has been from diet and lifestyle changes (which had the biggest impact on my health).

James @ Dadvice. TV

[vinadhun2 in reply to DadviceTV]

Thanks a lot for information.

I have started taking Renadyl.

Can i expect some improvement after one month at least to see downtrend for creatinine

[DadviceTV in reply to vinadhun2]

I did labs every 2 weeks while taking Renadyl and I only started to see changes around the 2 month mark. Things really improved a lot (at least to me) in the last labs. It takes time to build up enough good bacteria in your gut to metabolize enough of the waiste product that you don't see as much getting absorbed into the blood stream. Are you working with a renal dietitian - that was by far the most impactful thing I did.

James @ Dadvice TV

[vinadhun2 in reply to DadviceTV]

Thanks for the feedback.

Are you still taking Renadyl or stopped taking these capsules?

[DadviceTV in reply to vinadhun2]

I still take it, though I haven't had labs recently due to Covid. I feel amazing, have lots of energy, and no symptoms, so I'm in no hurry to visit a hospital. I do virtual meetings with my renal dietitian and PCP and am doing really good at sticking to my diet.

[vinadhun2 in reply to DadviceTV]

Just one last question on Subject of Renadyl:

Is it necessary to drink plenty of water along with these capsules?

I am taking capsules with my meals

[DadviceTV in reply to vinadhun2]

Renadyl doesn’t require any additional fluid intake, and most people take them with meals to help prevent any gas. For your overall health it is important to stay hydrated and your doctor can tell you how much water you should be drinking in a day based on your weight, activity level, medical condition, and other factors.

In the morning I take some BP meds, Renadyl, and a renal multivitamin. I take each tablet with a sip of water to help get my day started with some fluid (my daily fluid intake is 130 ounces - so this approach helps me drink that amount across the day). I eat my first meal around 11am and finish my dinner up by 6pm, then have my last BP meds around 9. This habit keeps me hydrated all day, keeps me from snacking near bedtime, and helps me sleep through the night. My BP meds are devised into 2 dosages to keep my BP controlled all day, and the evening dose has one pill that makes me tired.

I verified with Kibow Biotech (the makers of Renadyl) that it was ok to take it with my meds. The only medications they say not to take it with are antibiotics.

James @ Dadvice TV

[vinadhun2 in reply to DadviceTV]

Thanks.

Fortunately I do not have any health issue and I am not taking any other medicine.i do not have protein in urine problem. Nothing no issue except elevated creatinine which is around 1.80 and is stable since 6 months. Actually I took my first blood test in my life only in December 19 and since then upto now creatinine has been fluctuating between 1.74 and 2.09.

I hope that Renadyl works for me

[DadviceTV in reply to vinadhun2]

If all of your other labs are within the standard range (looking good) the first thing I would look at for managing creatinine is your diet and muscle health. For most people, only a small amount of creatinine in their blood comes from foods they eat. You'll want to make sure you are some consuming any supplements that contain creatine, make sure you are eating healthy (plenty of fiber, staying hydrated, etc.), and that you are getting the right amount of exercise (typically 30 minutes a day 5 days a week). An imbalance in your nutrition and a seditary lifestyle can lead to increased creatinine - and from my experience (I'm not a doctor, just a nerdy kidney patient) that is the best place to start when trying to manage creatinine levels.

I'm not sure if you fall into the category of someone who is likely to benefit from it. I don't want to burst your bubble - I love positivity and hope - but from knowing in pretty deep detail how it works and what it can do, it is more helpful for people who's labs are less under control. You may see an impact on your creatinine - but I honestly would be surprised when your other labs look good. If you told me your BUN is high, or some other issues, then I'd be expecting good results.

How are you doing with staying active and getting regular exercise? How is your diet - are you plant based or do you include animal proteins? I still eat animal protein - less than I used to, but I still have them. For those who eat animal protein, Renadyl could help - but the overall impact on creatinine reduction will be small since diet has a small impact on creatinine.

Just in case someone joins in to say you can eat a bad diet and your creatinine shoot up - yes, eating very badly will cause all sorts of issues, increasing the burden placed on the kidneys, leading to inflammation, etc. and will cause creatinine to sky rocket (along with other unwanted lab results). Being under nurished is also just as bad and can cause creatinine to spike. In these extreme cases, Renadyl isn't enough to help - it can't undo a bad diet. But for the typically CKD patient who understands we have to eat better, these extremes don't apply and diet has little impact on your creatinine levels.

Hope this helps - I can get very wordy.

James @ Dadvice TV

[vinadhun2 in reply to DadviceTV]

I have been going to Gym since 25 years and have been working hard at gym.i occasionally used to take whey protein and glutamine.

Of course I have completely stopped all protein supplements since 6months.

I am on plant based diet.

My BUN is under normal range.

As mentioned every thing is normal

Except creatinine. May be it is slightly elevated and stable.

But I am uncomfortable till it comes to normal.

I am following diet from renal dietcian. These days I do only cardio for about 50 minutes 6 days a week. No weight training

[vinadhun2 in reply to DadviceTV]

By the way I am taking normal multivitamin.

Which renal multivitamin is best?

[DadviceTV in reply to vinadhun2]

I take ProRenal+D with Omega 3. They make a version with Omega 3, but I suffered a heart attack in the past and have to be heart conscious. You can find a link to a video interview I did from just over a week ago talking about renal vitamins and ProRenal+D on my youtube page.

There is a very good chance your renal dietitian can give you a sample bottle. The version without Omega 3 is very small, about the size of an 81mg aspirin. The version with Omega 3 is larger and you take 2 gel tablets each day. A renal multivitamin has the things CKD patients typically need and none of the common ingredients we have issue with or that can build up.

James @ Dadvice TV

[DadviceTV in reply to DadviceTV]

I just noticed this put a giant thumbnail of the video in the post. The admins typically do not like links, so this may get deleted. My intention is not to promote content, I do not work for the company that makes ProRenal+D, I do not have an affiliate program with them, I get nothing if anyone purchases theirs or any other brand of renal multivitamin, and I do not have any stock in the company that makes it. This renal multivitamin is also recommended by the National Kidney Foundation. I'm not here pushing pills - just want to make that clear since admins are used to seeing bad stuff pushed on us.

[Dixidude39 in reply to DadviceTV]

James, based on your recommendation about 5 months ago, I began taking Renadyl, one capsule twice daily. Then began working with Jen Hernandez, a renal dietitian, and she had me start taking TWO capsules am and pm (total, 4 daily). From an eGFR of 28, my latest labs indicate an eGFR of 33. Creatinine and BUN are coming down.

[DadviceTV in reply to Dixidude39]

Outstanding - it is absolutely amazing how powerful working with a great renal dietitian is! I hope that one day soon it is the standard procedure for all doctors to do a referral to a renal dietitian for all kidney patients, instead of waiting for dialysis as so many do. I love hearing of people able to improve - you made my weekend!

James @ Dadvice TV

[maramax58 in reply to DadviceTV]

How did you find a good renal dietitian? I have been looking and having a hard time finding one

[Hidden in reply to maramax58]

If I may suggest going to eatright.org and when it opens look in the upper right of their home page for a red box. Open that, enter your zip code and you'll get a list for your area. Be sure to specifically ask if they have a certification as a renal dietitian. Should that not work out well contact the nearest dialysis center and ask if they know of one who is accepting new clients.

Best of luck.

[vinadhun2 in reply to Dixidude39]

how much was your creatinine and how much is it now?

[DadviceTV in reply to vinadhun2]

I was 2.52 when I started, then 2.25 at about 92 days later. This changed my eGFR from 29 to 33. My BUN was down from 42 to 28 - just 3 points above normal. The BUN impact was the most important to me personally - I have had so much trouble controlling it and it is highly impacted by your diet. Creatinine is mostly impacted by your muscle breakdown, though some foods and supplements can increase it some. I still enjoy animal protein - I know I would do better all plant based (I've done it for a short time and seen the improvements in my labs), but it is difficult to give up all animal protein long term.

With Renadyl you need to team it up with a good diet and it's impact on creatinine levels is less than it's impact on other labs. There is currently no treatment that will restore creatinine levels to normal when your kidneys are heavily damaged. I look at Renadyl as just another step towards better health. I want to make sure it doesn't come across as it will solve everyone's kidney issues. For some people, it can make apositive impact (which they can see on their labs).

James @ Dadvice TV

[Jyothish in reply to Dixidude39]

Are you still taking Renadyl did your gfr stabilized?

[vinadhun2 in reply to Jyothish]

It did not help me

[Jyothish in reply to Dixidude39]

Are you still taking 4 capsules of Renadyl per day and is your Gfr stable?

[vinadhun2]

I have started taking 4 capsules per day.

I will check my labs after one month I.e.on 28th August.

Hope to get good results

[Jamok]

I tried Renadyl last year but experienced horrible gas pains-like cut glass in my stomach. I would love to start taking it again for the benefits. Has anyone else experienced this and overcome it?

[Jyothish in reply to Jamok]

Start with one capsule after food and gradually increase to more.....

[Jayhawker in reply to Jyothish]

Did this probiotic elevate your potassium?

Jayhawker

[Jyothish in reply to Jayhawker]

No increase in potassium in my mothers case......