M3R receptor plays a role in remyelination

[dogdaddy]

multiplesclerosisnewstoday....

[erash]

Actually, the M3R receptor remyelination is a very interesting study as they used a common antimuscarinic called Vesicare that is use for over active bladder and incontinence. If this study continues to show success, we can address 2 MS symptoms at once.

Although I was surprised that an antimuscarinics which can cause some cog fog would remyelinate. Will have to see where this goes...

[dogdaddy in reply to erash]

Yes that's what the article says Vesicare....and I was thinking the same thing about killing to birds with 1 stone....but I unaware that antimuscarinics can cause cog fog...hmmmm

[erash in reply to dogdaddy]

It has anticholinergic properties

[dogdaddy in reply to erash]

Antinicotinic agents operate on the nicotinic acetylcholine receptors which ties into the other article I posted. They also have a long list of adverse reactions including Poor coordination

Dementia

Decreased mucus production in the nose and throat; consequent dry, sore throat

Dry-mouth with possible acceleration of dental caries

Stopping of sweating; consequent decreased epidermal thermal dissipation leading to warm, blotchy, or red skin

Increased body temperature

Pupil dilation; consequent sensitivity to bright light (photophobia)

Loss of accommodation (loss of focusing ability, blurred vision – cycloplegia)

Double-vision

Increased heart rate

Tendency to be easily startled

Urinary retention

Urinary incontinence while sleeping

Diminished bowel movement, sometimes ileus (decreases motility via the vagus nerve)

Increased intraocular pressure; dangerous for people with narrow-angle glaucoma.

Possible effects in the central nervous system resemble those associated with delirium, and may include:

Confusion

Disorientation

Agitation

Euphoria or dysphoria

Respiratory depression

Memory problems[14]

Inability to concentrate

Wandering thoughts; inability to sustain a train of thought

Incoherent speech

Irritability

Mental confusion (brain fog)

Wakeful myoclonic jerking

Unusual sensitivity to sudden sounds

Illogical thinking

Photophobia

Visual disturbances

Periodic flashes of light

Periodic changes in visual field

Visual snow

Restricted or "tunnel vision"

Visual, auditory, or other sensory hallucinations

Warping or waving of surfaces and edges

Textured surfaces

"Dancing" lines; "spiders", insects; form constants

Lifelike objects indistinguishable from reality

Phantom smoking

Hallucinated presence of people not actually there

Rarely: seizures, coma, and death

Orthostatic hypotension (severe drop in systolic blood pressure when standing up suddenly) and significantly increased risk of falls in the elderly population.[15]

Older patients are at a higher risk of experiencing CNS sideffects due to lower acetylcholine production.

A common mnemonic for the main features of anticholinergic syndrome is the following:[16]

Blind as a bat (dilated pupils)

Red as a beet (vasodilation/flushing)

Hot as a hare (hyperthermia)

Dry as a bone (dry skin)

Mad as a hatter (hallucinations/agitation)

The Bowel and bladder lose their tone (or "Bloated as a toad"; ileus, urinary retention)

And the heart runs alone (tachycardia)

WHICH MAKES ME LOOK AT THOSE VESICARE COMMERCIAL IN WHOLE NEW LIGHT

No thank you....if this is there best idea for remyelination I'll pass.

[erash in reply to dogdaddy]

Antimuscarinics like vesicare are more selective anticholinergics. These symptoms are possible but less extreme.