MTHFR GENE

[SometimesCrazy]

I was curious if anyone has been tested for this? Increased risk for a host of things. Migraines, fibromyalgia, chronic pain, mood, cardiovascular etc. You can't process riboflavin and something else so they become a toxin in your blood. I was thinking about purchasing the 23 and me DNA kit or see if my doctor will wr a lab order. Thank you.

[Royjr]

I’ve got to look that one up

[Jesmcd2 CommunityAmbassador in reply to Royjr]

I'm with you on that one Royjr 😐

J 🌠

[Betennant in reply to Royjr]

Used scholar.google.com for best references. There is a list out there that has what gene abnormalities are listed for what risk of disease. Sorry. If I am not clear. I am trying to do a little house cleaning and nobody told me my back was degenerating until this year. I don’t I know how you all clean house. I have done a man’s labor at one time, in the fields, in the camp, and raising a vegetable gardeni all while raising a son and helping out the SO with some hard chores also held down a job for 27 years. , but now I am 66 and feel like life is hopeless. Can’t even clean much of my house feeling my spine degeneration.

[Jesmcd2 CommunityAmbassador]

SometimesCrazy why would you want to borrow trouble?😐 Live for Today, and let tomorrow bring what it's going to!💕

J 🌠

[Betennant in reply to Jesmcd2]

Because it’s day after tomorrow. But the government talked about making people with gene flaws pay a higher insurance rate and that is discrimination. Be careful who you give out your info to.

[Iona60]

Do you know if this is what they call HLA factors? Recently, I saw a reference in an MS book that showed my HLA (which I had done 25 years ago) was linked to a very aggressive form of MS. My neurologist said that if this was true, I'd be much worse by now. So don't freak out if it comes back as a match.

[JackG1946]

You don’t need a scrip for the DNA test. You buy the kit and follow the instructions. Then mail the sample to them. It takes about 6/8 weeks for the results to come back. Go to their website. For more info. I’m waiting on my results.

[Qt314grl]

I did because it also affects fertility because you can’t process folic acid correctly. I have what’s known as compound heterozygous mutation. I have 2 alleles affected with one mutation. It’s better than having 2 mutations of the same allele affected. I take a baby aspirin because it can cause blood clots. I also take the methylated form of folic acid. I think it is good info to have.

[Betennant in reply to Qt314grl]

Yep, you can die from A Deep Vein Thrombosis. Anyone can have a genetic mutation. The gene mutation MTHFR is the one that causes birth defects or miscarriage and blood clots and is the MTHFR either one or a combo of two or the two copies of one or the other. Don’t ask.

[Betennant]

It is also implicated as a certain amount of risk for MS.

[agapepilgrim]

@SometimesCrazy Get the test!!!! My neurobehaviour counselor I go to for PBA and emotional roller coaster had me take the GENOsight DNA test to see why I have been on 8 different drugs for PTSD and chemical depression and all have negative reactions. Also, my neurologist insisted I switch from xanax to valium, and I insisted it wasn't doing me any good! THE DNA test came back that I have the MTHFR mutation and 2 allele mutations. It listed Valium as one drug I DO NOT metabolize. I took it to my neurologist but he said he doesn't prescribe xanax for anyone (yet, my sleep specialist had me on xanax for 8 years for sleep). Made me soooo mad I am never going back to him. I haven't been to a neurologist for 6 months and do NOT intend to go back. He said there was no other DMT for me to take; go to a pain clinic and the counselor. So, I am. My primary put me back on xanax, and my counselor put me on Lexapro, and Remeron. BUT, the most important addition that is so very important and making a LOT of difference is taking what she prescribed: L-methyfolate calcium 15 mg! It is the only supplement that will coiunteract the mutation. It must be 15 mg. I haven't been on the emotional roller coaster since starting it! I am finally metabolizing my meds!! It cost $30 a month, but I found it online for $75 for 3 months. A little cheaper. It's amazing the difference it makes!!! I know 50% of population has the mutation, but the DNA test will show if it is affecting meds. Mine came back 70% negative for assimilating valium, and some other drugs. Answered so many problems for so many years. On CBC I always show low protein, and usually have low albumin and blood in urine for many years. This also is caused by the allele mutation - I do not assimilate protein no matter how much I eat or drink protein drinks. Also, I do not assimilate salt. So, I put sea salt in all my water and seeds in everything to increase intake of protein. Also, there is a mutation that increases risk of Alzheimer's that will show up in the 23andME as written about in "The End of Alzheimer's." Since I have been diagnosed with early stage dementia, I am sure I have that gene, also. Since I already have dementia it is a waste of money to test for it. IF you are in your 40s, it's a great tool to prepare to stop progression of brain failure and MS with diet, supplements, and other protocols in her book. I am fighting this dementia with all the research I can find!!! With the mutations that were found in the GenoSight DNA test, I have a greater incentive to take necessary supplements in a form my body can assimilalate.

I would have answered sooner, but I have been knocked flat on my back with the worse case of double pneumonia I have ever had. I have chronic bronchitis and fatigued induced asthma, so those increased the symptoms, but this is the first time I have had pneumonia (I have had it about 20 times) with the progressed MS in my brain, stenosis and spondylosis, gastritis and esophagitis, so I was sicker than I have ever been in my life. I've been sick since Christmas; this week was first week without fever and chest pain, so I finally got to answer you. I had never heard of the MTHFR mutation until my counselor gave me the DNA test, and I am so thankful she cared enough to order it. The 15 mg L-methylfolate calcium is helping a lot. I recommend everyone with MS get this, especially if their meds are "not working." I pray you find your answers.

[SometimesCrazy in reply to agapepilgrim]

I just read your reply. Seemed very important about the mutated gene for everyone. Niacin and folic is unnaturally added to so many products. Its the altered byproduct. mb15 mgbmethylfolate is now on my very to do list ! I will let you know. I'm very sure about the POST self diagnosis. Of course I'm waiting for diagnosis from doctor next month. Seeing doctor next month. Then however long. Xxoo