Fluorouracil cream

Over the last couple of years I have developed a pre cancerous spot

in the back of my hand, I am 79 years of age. My doctor gave me a tube

of the above cream but after applying it twice a day for 4 days I got the

most horrendous stomach cramps and diarrhea. What surprised me

was that the ( spot ) is very small and I can hardly believe the effect is

so bad, I am prone to IBS so maybe thats the answer. Are my problems

the result of using this cream or my IBS which is now generally under

control. Can anyone help.

3 Replies

  • Hi, I have not used this but a quick search in "Cancer Research UK " shows it can give diarrhoea - cancerresearchuk.org/about-...

    The medicine pack should have leaflet from the manufacturer - you may want to read it (possible side effects), although most manufacturers will include almost all possible common side effects, so sometimes it is hard to make a judgement.

    But, since it is a type of chemotherapy drug, this diarrhoea and stomach cramps easily occur as side effect. I hope you would not need to use it for long - but it is best to consult the doctor if the diarrhoea lasts for more than 3 days - and I am sure you know, you need to keep drinking lots of fluids - I am sorry to hear this and I hope you will feel better soon.

  • Hi thanks so much for your imput, it is listed as a side effect but

    it was so immediate and my ( spot ) is so tiny I couldnt quite

    believe that the effect could be so bad. I used it twice more with

    the same result so I stopped using it. The stomach cramps are

    still bothering me slightly. I contacted my GP and Im waiting for

    a call just now. Thank you.

  • I have spoken to my GP now and he says that the cream

    wouldnt cause this problem... and I should wait until Im

    fully recovered and then restart the cream. I will do as he

    asks but stop if I experience any problem.

    Im not convinced at all because as you pointed out the

    leaflet does warn of this possible side effect.

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