MSA trial near completion: Hi I am new... - Multiple System A...

Multiple System Atrophy Trust

1,774 members1,425 posts

MSA trial near completion

Downhillracer profile image
4 Replies

Hi I am new here and I have MSA. I have been searching for all the info I can find. No real drugs to even slow this. I have read B vitamins are helpful' Possible good news, recently a team from Vanderbilt University in the US released interim results from a small study of their drug ATH434 at 6 months.

43% of patients showed improvement on UMSARS activities of daily living scale

29% had stable or improved neurological symptoms

No safety issues

This is just a tiny open label trial, so cannot be considered as any sort of proof.

They have another trial running which is a larger double blind trial, complete in November on earlier stage MSA. Reporting results Jan next year. That is ATH434-201 Phase 2. That could be interesting because all the improvers in the open label study were early stage. Fingers crossed.

Written by
Downhillracer profile image
Downhillracer
To view profiles and participate in discussions please or .
Read more about...
4 Replies
Gill-C profile image
Gill-C

Got to keep looking forwards! Thank you for the information

Gill

Monkeyfeet1 profile image
Monkeyfeet1

thank you for the information xx

Worbs2 profile image
Worbs2

They talked about 3 phase in summer of 2025. I was in ATH434-201 Trial. Hopeful,Ron, MSA-C PATIENT

Downhillracer profile image
Downhillracer in reply toWorbs2

i hope it did you some good. I am still early stage. These guys have been working with different metal chelators on neuro diseases for decades. In this case they did ATH434 animal studies on several neuro disease and MSA was a standout. That is why they went after MSA with the 201 (your study) first and why I am optimistic for success. The promising recent data reported from the 202 open label makes me very confident of some success, finally. But I have been wrong before:-)

Not what you're looking for?

You may also like...

MSA Trust Community Guidelines

Welcome to the MSA Trust Community at HealthUnlocked! The goal of our community is to provide an...
EmmaMSA profile image
Partner

Advanced MSA / Towards the end

Like so much to do with MSA, this is a difficult subject to write about. My wife, just turned 60,...

MSA medication

My husband was diagnosed with MSA in July and was started on Sinemet straight away. In all this...
Redjune1 profile image

MSA Clinics

👋 everyone, hope you're all as well as can be expected and looking forward to Christmas.Please...
Frenchoak profile image

MSA

Hi I was diagnosed with MSA in August this year and went for Stem cell treatment in September. I...
Ohmdotcom profile image

Moderation team

See all
MSATKirsten profile image
MSATKirstenAdministrator
JamesMSAT profile image
JamesMSATAdministrator
NicoleMSA profile image
NicoleMSAAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.