MSA trial near completion: Hi I am new... - Multiple System A...

Multiple System Atrophy Trust

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MSA trial near completion

Downhillracer profile image
4 Replies

Hi I am new here and I have MSA. I have been searching for all the info I can find. No real drugs to even slow this. I have read B vitamins are helpful' Possible good news, recently a team from Vanderbilt University in the US released interim results from a small study of their drug ATH434 at 6 months.

43% of patients showed improvement on UMSARS activities of daily living scale

29% had stable or improved neurological symptoms

No safety issues

This is just a tiny open label trial, so cannot be considered as any sort of proof.

They have another trial running which is a larger double blind trial, complete in November on earlier stage MSA. Reporting results Jan next year. That is ATH434-201 Phase 2. That could be interesting because all the improvers in the open label study were early stage. Fingers crossed.

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Downhillracer profile image
Downhillracer
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Gill-C profile image
Gill-C

Got to keep looking forwards! Thank you for the information

Gill

Monkeyfeet1 profile image
Monkeyfeet1

thank you for the information xx

Worbs2 profile image
Worbs2

They talked about 3 phase in summer of 2025. I was in ATH434-201 Trial. Hopeful,Ron, MSA-C PATIENT

Downhillracer profile image
Downhillracer in reply to Worbs2

i hope it did you some good. I am still early stage. These guys have been working with different metal chelators on neuro diseases for decades. In this case they did ATH434 animal studies on several neuro disease and MSA was a standout. That is why they went after MSA with the 201 (your study) first and why I am optimistic for success. The promising recent data reported from the 202 open label makes me very confident of some success, finally. But I have been wrong before:-)

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