A couple of months ago a hematologist put me on HU. Since then I've had a cough, sore throat, and red blotches on my neck and chest, and my fatigue has increased. I had fatigue already from 6 years of PRV, but now have even less energy. The specialist said that these problems wouldn't be caused by the HU, but I think it definitely is. Has anyone else had similar reactions from HU? A phlebotomy has not changed anything.