Besremi and reduction in allele burden.

[WIL2US]

Hi! I have been on besremi for almost 2 years. I have PV and ET. My AB at its highest was 58 it is now 25. I am wondering if others are able to reduce besremi or if anyone has reduced their AB to zero. Does that mean you no longer have PV?

[hunter5582]

My JAK2 VAF has reduced from 38% to 10% on a 175mcg dose of Besremi. I hope it will go lower but cannot raise my Besremi dose to achieve that outcome.

It is reported that about 25% of people on Besremi achieve a complete molecular remission (CMR). There are a number of factors that influence this outcome, including dose and non-driver mutations.

It is not yet clear what it means to achieve a significant reduction in VAF or a CMR. There is not evidence that a CMR is a cure for PV. This is an area of active research. At this point I think the best way we can put it is that a reduction in VAF is a good thing but we cannot prove how good it is. Yet. Hopefully we will know more in the near future.

All the best.

[WIL2US in reply to hunter5582]

Thanks so much for the information. It is pretty confusing but hopefully it is a good thing.

[Gladys1208]

Hi

I’m on Pegasys, not Besremi, and have found out this week that my AB has reduced from 88% when I began Peg, to 22% after 4 years of interferon treatment.

I asked my consultant if my consistently ’normal’ blood counts meant I was in molecular remission, but apparently she’d need to see an AB of 0% for that.

Instead, my results are referred to as a’a good molecular response’.