rash on feet

[HazeBlue]

anyone else have problems with itchy rash on feet whilst taking hydroxycarbamide ?

[hunter5582]

While rash and other skin issues are a potential hydroxycarbamide adverse reaction, a rash on the feet can occur for other reasons. Suggest you have this assessed promptly as an infectious rash will just get worse without treatment.

[liarose]

yes I had rrash on my feet. In fact it spread up my llegs and have tried various creams on them via dermatology

[hunter5582 in reply to liarose]

That does sound more like an adverse effect. Suggest a consult with hematology is in order since it seems dermatology is resolving the issue with topical treatment. Hopefully, you gave a MPN Specialist on the team who is familiar with how these adverse effects manifest.

[lizzziep]

I developed a rash on my feet, after being on hydroxy for 3 years, it didn’t go away, but developed into ulcers, which were extremely painful, eventually saw a dermatologist who said straight away it was a reaction to the drug. They didn’t clear until I came off it and on to Anagrelide. So take care and have it looked at!

[HazeBlue in reply to lizzziep]

I would like to try Anegralide but hear there are also side effects . Thanks for reply .

[hunter5582 in reply to HazeBlue]

The kind of rash that turns into ulcers is a very severe adverse reaction. It risks progressing into gangrene. Vasculitic ulcers are an absolute contraindication for HU when they occur. Other adverse effect rashes that would be considered serious include dermatomyositis and lupus erythematosus. That is not to say that what you are experiencing is any of these more serious things. It could be something minor; however, it is best not to take chances or make assumptions. Have this checked out as an emergent issue in the context of being on a chemotherapy with potentially serious dermatologic adverse effects.

I would note that while I did get very bad oral ulcers on HU, I never had any skin issues. I did get some mild rashes and itching on the interferons, however. The skin issues are well managed with a daily dose of cetirizine (oral antihistamine). I did not make assumptions when I encountered this side effect. I consulted with my MPN care team and the specialty pharmacy. PharmaEssentia also called me to consult on the issue since I am enrolled in their monitoring program.

We are all different in how we respond to these medications. If you find the HU does not suit you, then Pegasys and anagrelide are both options to treat ET. You may find one of the other options works better for you. Hopefully, we will soon be able to add the ET clinical trial drugs to the list - Bomedemstat, Jakafi, Besremi, and more.

Wishing you all the best.

[Trueblue8]

I was recently referred by haematology to dermatology, another 'ology to add to the ever growing list, as I have a rash on my lower legs and feet.Thankfully reassured by dermatologist that it's something called Telangiectasia/capillaritis, which is benign and therefore nothing to worry about.

Hope that helps?

Ian

[lizzziep in reply to Trueblue8]

I was on Anagrelide for a few years, I had a few palpitations when I first went on it, but not bad ones, then they faded and I only got them occasionally, otherwise was ok. But everybody’s different. I’ve progressed to MF now and m on Ruxolitinib.

[Bluetop]

I have just resturned from haematology appointment to ask that very question. I have a particularly sore toe which has been swollen, is now normal size but still sore. The toe has much improved in the warmer weather. Also on both feet I have a rash, under the skin which tends to be more prominent at different times, but doesn't go. It does not itch. The haem thought this was erythromylalgia and suggested increasing the asprin dose if the problem becomes severe in colder weather. So his thought was that it was PV related, rather than a reaction to hydroxycarbomide.

[Tipsy2023]

Hi I do have same problem but for me it has I think more to do with ET than medication . When I started Hydroxycarbamide it was practice with my haematologist to take Allopurinol for first month this did help the itching and redness … so I wonder if it relates to cell breakdown which increases with medication . I was undiagnosed. From 2015.. my feet were terrible from then which included nails … a little improvement now I have also been put on anti fungal medication in last couple of months which is helping. Good luck L