Change in bone marrow fibrosis during mome or Rux therapy do not corelate with efficacy outcome to patient with Mylofibrosis

[william-Indo]

Here a new research published by MPN team lead by Dr. Ruben Mesa

onlinelibrary.wiley.com/doi...

Hope it will useful

Cheers

[TLJ-1]

A little discouraging, but informative.

[EPguy]

These plots show the result graphically. Same less or more fibrosis (BMF) didn't matter on survival.

Any difference actually pointed to negative effect of reducing fibrosis, but not statistically signif.

Brings up a question: If BMF is not relevant, might VAF be? Some MF pts do get a VAF response. I'm not aware of any study with this endpoint.

RxMMB