Is it normal for someone with ET to have blasts percentage 1%-2% in the bone marrow?
Is it normal for someone with ET to have blasts ... - MPN Voice
Is it normal for someone with ET to have blasts percentage 1%-2% in the bone marrow?
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If I remember correctly normal bone marrow contains 0-5% blasts.
That’s correct, I was 3%- 4%
Hi Paul, do you know if these are the same as the blasts seen in the blood film morphology?
Blasts should not be seen in the blood from an article that i read. I suppose blasts in the blood is a a different situation.
Thankyou for your reply
You should only see blasts in the blood with leukemia or myelofibrosis...never with ET or PV. They are immature cells that have been pushed out of the bone marrow too soon because it has become fibrotic.
Thankyou for your reply, I have post ET/MF and had blasts of 2% on my last two visits to the hospital. Will need to clarify the meaning of this at my next visit.
I'm guessing it was in the blood since they even mentioned it to you because that percentage would be normal in the bone marrow even in a person without a MPN. Of course that's just a guess. I think in myelofibrosis you can have up to 20% blasts in your blood. Once you surpass 20% you are then considered to have AML. I hope you are able to continue watch and wait for many years to come.
Thanks once again for the information, I am a 45 year old male and I was ET CALR mutation for approximately 8 years prior to the MF diagnosis, there is so little information out there re progression and any help from fellow MPNers is much appreciated.
So you're a young one too? I was diagnosed in my 20s and I worry about transforming to MF. The good news is that although CALR positive people are more likely to transform to MF when we do get MF it is usually not as aggressive as it is when JAK2 positive people get it. My doctors have never given me much information at all so I research everything on my own. My background in the veterinary field helps me decipher some of the complicated papers but I can't imagine trying to decipher those papers/studies without any medical knowledge.
My understanding is that blasts in blood imply a different diagnosis to blasts in marrow.