Hi, me again.Jak2 positive ET. On aspirin since 2018, and HU since 2019. Platelets this week are down to 366 and HCT risen to 0.503
Last review three months ago, platelets were 450.
My query is, how safe is it to allow the platelets to drop? My next haem opa was thus week, but cancelled by them and now end of November.
Thanks for your time.
X
Answering your question completely would require more information. It is worth noting that a normal platelet range is typically considered to be 150 - 450. Provided you do not drop to the level of thrombocytopenia, your body should still have an adequate ability to stop bleeding.
It is also worth noting that the hematocrit values need to be monitored. The diagnostic criteria for PV include Hematocrit > 49% (men) or Hematocrit > 48% (women). While there could be other explanation for a rise in HCT, in the context of a rise in HCT while taking HU for ET, this issue needs to be explored. Suggest that waiting 11 months to check on your status is not acceptable.
I would note from my own experience that when my ET progressed to PV my old hematologist misdiagnosed me. It was not until 5 years later that I found out the MPN had progressed. The treatment protocol for ET and PV is not the same. Suggest you need to ensure that you are following the proper protocol. The only way to do this is in consultation with a MPN expert provider. You may want to consider referral to and MPN Specialist and be seen promptly. mpnforum.com/list-hem./
Wishing you all the best moving forward
you are within normal range . They should reduce your medication to keep it stable . I changed to Interferon now. Haemotology should advise but if slow contact MPN to oversee treatment 👍
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