Was doing some mpn reading (my new hobby haha) and came across this potentially new treatment for those of us who have CALR mutations. I thought this was interesting and wanted to share. Not sure if it already has been shared.
Hope is percolating out there! This is the second article I’ve read in a month on a potential “fix” for mutant CALR cells.
meduniwien.ac.at/web/en/ueb...
Have a good day
I've not heard about hematoxylin before. Neat possibility. It is an old natural compound so would be easily available. But I don't see it as a standard drug or supplement, more as a solution for science experiments. So I think it would need to confirm any toxicity issues.
This study is quite early so CALR patients would not be getting it for a while.
There is esp exciting research lately with immune therapies, ie CAR-T for CALR. There are some recent posts on it.
It seems CALR is an easier target in some ways than Jak2.
Very interesting article. The "good news" about CALR is that it is the one MPN mutation that actually causes a change in protein at the surface of the mutated cells. This allows the potential for these cells to be targeted and destroyed while leaving wild type (unmutated) cells intact.
It is good to see hope for emerging treatment options.
Thank you for posting this interesting research article. As a patient with CALR Type 2 E.T. It’s very encouraging to hear about research that may lead to more effective treatments and hopefully one day a cure.
Hi welshhuwI to have been diagnosed with ET Calr +, as platelet count was high last year after blood test.
Recently blood tested and levels at 377 on hydroxycarbamide so promising to get this news as were 1600 2 months ago.
Im 46 this year, so still young.
Promising to hear about research of treatments for this condition, as long term goal is hopefully to live a normal life and this will not progress.
I am meeting a professor ay Guy's hospital later this month. I shall ask about this treatment.
Will update accordingly, if i can find this thread.
Smudger
Thank you for sharing that. Have you come across any more recent information on this?
The other study that I heard about involved an antibody that was discovered in Australia, is that the other one you’re aware of?
Interferon effects on Calr alleleborden
