My wife was diagnosed with ET in the early 90's and started on Hydrea then moved to Anagrelide. Then it progressed to MF and she was on Jakafi and then Inrebic which stopped because of very low platelets and hemoglobin. Then she started courses of weekly infusions of Azacitidin along with two weeks of Venetoclax. She completed six courses and now she is on Vonjo. After being on it a week platelets are above 39K and hemoglobin has not dropped below 8. Big change from biweekly transfusions with platelets still staying in the low teens and HGB below 7. No reduction in spleen yet but maybe in time.
On to Vonjo: My wife was diagnosed with ET in the... - MPN Voice
On to Vonjo
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That's great news. Vonjo is supposed to do that, treat MF with low PLT counts. To see it doing what they claim is reassuring.
<<for the treatment of ...myelofibrosis with a platelet count below 50 × 109/L.>>
For the spleen <<29% of patients had a reduction in spleen volume of at least 35% compared to 3% of patients receiving best available therapy, which included ruxolitinib>>
So on Rux almost no chance of spleen improvement here, while Vonjo has much better chance and spleen reduction was a big reason it got approved quickly.
It is a blessing that the options for MPN treatment are expanding. Vonjo is a great option that will hopefully be successful for your spouse and others.
All the best to both of you.
Wonderful news . I have ET so never heard of vonjo. It’s reassuring to know that these meds exist. I do wish your wife’s condition continues to improve.
Sounds like good news. Hoping and praying for continued improvement for your wife. Best going forward.
I was not expecting a 11k platelet increase so soon. She has two proactive MPN specialists in addition to exceptional pros in many health fields who are a blessing for her.
So pleased you are getting some positive results. All the best.
This is encouraging news. I really hope everything continues to go well for your wife. Hope you’re getting good support too. X