Extremely worried about the value of IL-6 and IL-8 explored, what should I do?

[merlisa]

I'm 34 years old only, and have been in MF3 since 2017 diagnosed. Very bad state I was megalosplenia when I diagnosed. Now I take Ruxolitinib 7.5mg/bid /day and interferon per several days. The hemogram was controlled lower than normal, especially platelet. I have taken Ruxolitinib for 3 years, obviously, I have felt the intolerance on the platelet. Once i took Ruxolitinib 10 mg/bid, due to intolerance, to decrease now 7.5mg/bid. Interferon keep as previous.

Now I'm very worried about the the value of IL-6 and IL-8 explored, the value of IL-6 and IL-8 are more than 40pg/mL, while the normal value should be less than 11.09pg/mL and 15.71pg/mL respectively. almost more than 4 times. when I took 10 mg/bid Ruxolitinib, the best state of IL-6 and IL-8 were almost close to normal. But if I increase Ruxolitinib dose, my platelet will fall.

MPN person can try some medicines about IL-6 inhibitor? as i know, rheumatic immune diseases have similar drugs.

So, who can help me on this issue?

[Otterfield]

I'm sorry I can't help with your question, as I haven't heard of IL-6 or IL-8. However, I am also on Ruxolitinib and my platelets are low too - 27 at my last blood test. My haematologist is not concerned about this, although I worry about bleeding in case of an injury. I suggest that you ask your haematologist to explain all your results.

Best wishes

[merlisa in reply to Otterfield]

Indeed, you don't need to worry about it. Ruxolitinib controls your value-added rate, not the total value-added. No matter how many platelets, it doesn't affect on you taking Ruxolitinib. And Ruxolitinib has another function on inhibiting megakaryocytes. After megakaryocytes mature, the epidermis falls off and becomes platelets. so, finally, the platelets will decrease and decrease. But without medication, the situation will only be worse. Now many people are facing such a problem. So do I. Maybe it belongs to the intolerance of this drug. There are many similar with Ruxolitinib drugs now, such as Fedratinib or Peficitinib etc. may we can change them each other to solve bad side effects.

[hunter5582]

The role of the Interleukins in inflammation and immune response is quite complex. Understanding what is going on would require a very detailed analysis of a number of factors. The two WIKI articles give a good brief summary of these two ILs.

en.wikipedia.org/wiki/Inter...

en.wikipedia.org/wiki/Inter...

It is important to understand that at the core MPNs are inflammatory disorders. The dysregulation of the JAK-STAT pathway causes our bodies to make too many inflammatory cytokines, possibly including the pro-inflammatory Interleukins.

It will be very important to review your concerns with a MPN Specialist. There may be more than one thing going on, but it is certain that the MPN is part of it.

Hope you get answers soon.

[Wyebird]

To have MF at your age is a huge burden. I’m really sorry I wish I could help you but being ET Calr means a lot of what you posted meant little to me. I do hope someone cane help you.

[EPguy]

Seeing your old post here. Are you feeling ok?

Have you learned any more on your inflammation? You're unusual taking both INF and Rux. It has been studied but is not standard practice that I've heard about. Why did your Dr give you the combo therapy? I see the Rux reduced your inflammation, which is I believe how it was studied with INF.

This study suggests Rux can improve IL-6 effects.

pubmed.ncbi.nlm.nih.gov/291...

<<results demonstrated that small drugs acting as JAK inhibitors,like ruxolitinib, counteract IL-6-mediated repression of drug-metabolizing enzymes>>

Which one, INF and Rux, did you start first?