Methotrexate users have a reduced immune response to mRNA COVID-19 vaccine

[socrates_8]

Post by MPN-MATE Admin » Wed May 26, 2021 2:37 pm

Afternoon all...

Just recently discovered this article concerning patients, (such as myself), who might also be taking Methotrexate (MTX), as part of their MPN treatment. Apparently, being on MTX can disrupt the effectiveness of the Pfizer Vaccine, please see below for the full article & reference.

Best wishes

Steve

mpn-mate.com/forum/viewtopi...

[piggie50]

Very interesting Steve, after reading this and the results of my blood test , I must assume I am not protected..I will carry on being vigilant.

Thanks for posting

Judy 😁

[socrates_8 in reply to piggie50]

Hey Judy...

No, not completely conclusively as yet... But there seems to be that correlation is a distinct possibility etc...

They have just upped my MTX dose too, on top of my Rux 25mg b/d etc...

Interestingly, my Specialist offered me Pfizer vaccine today, saying that because of my condition, I might be subjecting myself to greater risk w/ AZ etc...

Having had a few TIAs, and also Acquired VWS means I am already suffering from a clotting problem once my Platelets are north of that magic 1Million marker...

As of today, I will also commence Dual Anti-Platelet Therapy (DAPT), which is Low dose aspirin combined w/ clopidogrel.

Next bloods might be interesting too...

Best wishes

Steve

[mhos61]

Thanks for this Steve.

It is of particular interest to me, as my hubby is on this drug, and I’m always wary of his immune response to such things. I thought the advise of temporarily stopping the drug to boost immunity was worthy - under medical advise of course. I had also thought why this wasn’t considered, as it is advised when an infection is present or antibiotic treatment is needed obviously to boost immunity!!

Interestingly, we have both had the vaccine antibody test with ‘Testing for All.’ Anything above 0.8 U/ml is considered a positive for antibodies against the Covid Spike protein.

My result was 2239 U/ml four weeks after the second AZ vaccine. My husband’s was 579 U/ml five weeks after second AZ vaccine. This is out of a possible 2500. So, it seems for him, he’s had a response, but obviously not as robust as mine.

I hope Judy sees this, as she’s also on methotrexate and her results showed a negative response to the vaccine.

Do you still take methotrexate Steve?

[socrates_8 in reply to mhos61]

Hey Mary...

Yes, they've just increased my dosage too...

However, yours & your hubby's results are worthy & encouraging all the same...

I have some other added complications w/ clotting that make me an unsuitable candidate for AZ...

Thanks for sharing Mary...

Best wishes

Steve