Potential New MF Drug

[socrates_8]

CPI-0610 Demonstrates Activity in Patients With Myelofibrosis After Ruxolitinib Failure

Post by socrates_8 » Tue Aug 20, 2019 7:43 am

Morning everyone, thought some of you might find this of interest.

Being an MF patient myself I am always wondering what I might be looking at as my next line of treatment therapy, if and when my Ruxolitinib completely fails me, which it might be beginning to do at the present... (?)

This might be one solution... So keep an eye out for 'CPI-0610'

mpn-mate.com/forum/viewtopi...

Have an awesome days guys...

Steve

[Fika500]

Thank you Steve. My husband is in a similar situation to you, fearing the point when Ruxolitinib fails him. He’s fighting an infection at the moment, his platelets are down -78 two months ago , last week 44 and this week 21. Hgb has also gone down from 106 on EPO injections to 91. They’ve temporarily suspended his Ruxolitinib to be reviewed in two weeks. They’re talking about reducing it from 10mg twice a day to once a day.

I wish you well and am very grateful for all the helpful information you provide , especially keeping us up to date with new developments. Thank you.

[socrates_8 in reply to Fika500]

Hey Joe500...

You are most welcome, I simply wish that I had more to offer your hubby in his time of real need...

Hopefully, they will have him sorted out shortly, such is my fervent hope of course...

There is also another new/old drug that has recently undergone a new series of clinical trials and has now been re-approved in the USA, it is called - Fedratinib (Please see the Link below)

mpnresearchfoundation.org/F...

The MPN Research Foundation often have a lot of very pertinent information across their website so well worth signing up to their newsletter, in my view...

As I understand it, it was redeveloped for those for whom Ruxolitinib has also largely failed, and where thromboctyopenias have lowered platelets & Hgb... worth looking into at least. Maybe ask Prof. Harrison for her opinion?

Hope this might help...

Best wishes

Steve

[Fika500 in reply to socrates_8]

Thank you so much Steve.

[socrates_8 in reply to Fika500]

No problem, and please stay in touch and let us know how things develop... and remember that we all care & support each other here...

Best wishes

Steve

[hackett]

Hello Steve Long time I have not written.. I am ok atm with my other cancer . But I was more writing to say that when fedratinib was being trialed I was one of the trialees out of Pow in Sydney, and yes it worked as well as if not better than/as Jakavi. And then it was abruptly stopped and I went back onto Anegrilide for a while. I hope all is well with you!!! Jan

[socrates_8 in reply to hackett]

Hey Jan...

Great to hear from you... Glad to hear you are doing ok too...

And why haven't you signed up to our new Aussie MATEs FORUM as yet?

mpn-mate.com/forum/viewforu...

Have an epic Fundraiser underway these days too:

mpn-mate.com/sponsors/

Here's my first short Promotional Showreel:

youtu.be/PKPlpsSExho(Not working as expected?)

I trust your lovely wife is also doing well... Pity you were not able to make our last Cafe Catchup in St Ives, as it was a really good afternoon for all in attendance. But yes, I realise much greater distances for you to travel in order to attend too...

Anyways Jan, that is a truly fascinating insight that you have had w/ Fedratinib, and that trial. Seems, like as is the case with many other drugs, we can each have varying outcomes through our very differing body chemistries etc...

I am hoping that it might be useful for me, as I am still struggling a tad here w/ my Ruxolitinib not really keeping my platelets under raps any longer...

Please do stay in touch Jan, great to hear from you..

Very best wishes...

Steve