Interesting trial, replacing need for Chemo in SCTs.

[Paul123456]

Very early days and I don’t know how applicable it could be to MPNs/MF. Will ask my Hem next time.

Could be a game changer for us. Basically, if we live long enough (that may be over 100 years for some if slow progression!) we get MF. Trouble is current Chemo SCT treatment is high risk, with risks rising dramatically the older you are. Hence, by the time most of us progress to MF, there will be a significant % too old/infirm for survival odds to be acceptable.

Sounds like this new trail offers, in principle, a possible cure even for the elderly?

My thinking has always been stay as fit and healthy as possible for next 5 - 10 years. By then I am confident that our treatment options will be much improved. This link is proof of the progress being made behind the scenes.

med.stanford.edu/news/all-n...

[Garden987]

Hi Paul. What exciting news! Thank you for researching this information. It seems you spend a lot of time looking for information and it is very much appreciated. Fingers crossed everyone and thank you again Paul. Mary

[Pippa63]

Hi Paul. Very interesting read . Thanks for sharing this info with us . it seems there's always hope with all the research that's going on of which most we are unaware of . Thankyou

[Rachelthepotter]

Thanks, Paul. I appreciate your sharing the research you find out about. I’m seeing haem at Guys on 12 th March so I ‘ll hope to get his views then. As a 68 yr old with MF I’m not especially hopeful. And getting very fed up of the tiredness and brain fuzz.

[Timjonze]

Great to read these developments Paul - really appreciate you posting them

[crapaud]

Hi,

Good news concerning the chemo/radiation side of things but don't forget that the majority of issues (when they occur which isn't systematic) are due to GvHD after the SCT.

Obviously by making life easier to 'clean out' the defective stem cells is a big bonus all the same.

Gary

[Paul123456 in reply to crapaud]

crapaud

I’ve posted this link before re recent Graft Host trial. Looks encouraging?

news-medical.net/news/20171...

Best Paul

[crapaud in reply to Paul123456]

Hi Paul,

I agree it looks encouraging - wasn't around when I had my SCT so I did suffer a little from GvHD (both acute and chronic) but have pretty much pulled through now.

Very encouraging for those needing an SCT in the future though.

Perhaps in a not too distant future with improved preparation (chemo/radiation reduced) and better 'protection' from GvHD the SCT will no longer be considered as the 'last resort option' but a way of avoiding long treatments.

All the best

Gary

[Betsywest]

Thanks Paul for posting, very interesting. I find your posts always so positive in giving us all a boost by reminding us what’s going on out there to help all our futures..

[Mrs_Average]

Very interesting Paul. Thanks for sharing.

[pj1963]

Paul, your posts are always interesting and help us all try to stay positive.

Paula

[Indigo42916]

Paul,

Thanks for sharing, chemo is definitely a double-edged sword, using something to treat cancer that causes cancer. The bottom line is the stem cell defect has to be remedied, and chemo can't do that.

I am with you on your approach, staying as healthy as possible, waiting for some more biologic options.

Thanks for sharing this.

Take care.

[Tintins]

Hi Paul.. Thank you very much for posting this research. It is comforting to see the scientific progress that mighthelp us all in the future.