I wonder if some of you do not have support from family and friends and if so how you cope. I have ET - JAK2- and am being investigated for MPL, CALR and ..MA? plus further blood tests because of debilitating fatigue. I also have CFS so the fatigue could be associated with that. I live alone and have only my daughter who tries to be supportive but I know she is finding things difficult. I walk as often as I can but that is infrequent and a huge struggle. After a hospital appt. I am totally wiped out for 2days and with no help things are difficult. I do try to stay positive but, like today, am finding life a huge struggle. Any words of advice or comfort will be much appreciated.