Hi, anyone got any experiences of reducing pegasys dosage? I was initially prescribed 45mcg once a week about a year ago. Platelets dropped quickly. For the past 4 months I have been taking 45mcg every 2 weeks. Platelets seem to stay within 300-350 range but have been experiencing some ET-like symptoms : increasing tiredness, occasional dizziness and headaches, some nausea. (BTW: one reason for reducing dosage was raised liver enzymes which have now lowered on fortnightly Pegs). Would be very grateful to hear others' experiences. This dosage issue seems a very inexact science!!