I discovered I had PV C 27 months ago after a routine blood test. I was put on a low dose of HU which did not agree with me. I had every known side effect and began to feel suicidal. I changed consultants and am now on my third who is trying to keep me off medication as most drugs do not agree with me and my allergies. I have been off the HU or 44 days and my platelets are now in the 700's and rising. There does not seem to be any correlation between my blood test results and time, the nasties just go up at varying rates.