I thought I would share my experience with Topiramate as it caused a few issues for me. I was given it as a 'last resort' treatment and was told that it wouldn't cause me any problems. I started on a very low dose and it was increased as per the recommended guidelines, ie weekly. This turned out to be too quickly as I wasn't able to function properly, it wasn't safe for me to drive and I didn't like the feeling of being 'not with it'. The increase was then slowed down to every 2 weeks. After being on this drug for about 2 months and noticing a big difference in the amount and severity of attacks, I had a routine blood test. The results came back that I had kidney damage which was definitely the result of the Topiramate so consequently I was taken off of it very quickly. Needless to say, the migraines returned but thankfully the kidney damage was reversed and back to normal after a couple of months. I'm now waiting for botox treatment next month and looking forward to the results. I'm sure that Topiramate has helped a lot of sufferers but, if you're one of them or you're going to try it, please ask for routine bloods to make sure that everythings ok.