FDA Approves Tecentriq for First-Line Treatment of Metastatic NSCLC with High PD-L1 Expression

[Miranda_GO2]

On May 18th, 2020, the Food and Drug Administration (FDA) approved Tecentriq (atezolizumab) for the first line treatment of advanced non-small cell lung cancer (NSCLC) with tumors having high expressions of PD-L1 (>50%) and no changes in EGFR or ALK. The FDA based their approval on the results of the clinical trial IMpower-110 which showed that patients receiving Tecentriq (atezolizumab) lived longer, had a higher chance of responding well to treatment, and went longer periods of time without progression than those receiving chemotherapy.

Tecentriq (atezolizumab) being available as a first line immunotherapy option for NSCLC gives patients more options for first line treatments than ever before.

Read the full release here: fda.gov/drugs/resources-inf...

[Denzie Moderator Volunteer]

Thanks Miranda! This is the 4th treatment approval in 2 weeks. I can’t remember another time in lung cancer advocacy like this. Amazing. Just amazing.

[Miranda_GO2 Partner in reply to Denzie]

It's incredible. Jennifer King (GO2's Chief Science Officer) is writing a blog about all the approvals this week. Despite COVID-19, new approvals are being made. Very thankful for that! I'm be sure to share the blog post by Jennifer once it's done!

[Pollypeck in reply to Miranda_GO2]

Is there a link to to this blog? best, Nadia

[Miranda_GO2 Partner in reply to Pollypeck]

Hello,

Here is the link to the blog post about all the drug approvals last summer: go2foundation.org/blog/scie...

And here is the link to the general blog: go2foundation.org/blog/

Please let me know if you have any questions. If you sign up for GO2 email updates the blogs will be included in the newsletters.

The

[Seaspray298]

Been on this drug for over a year but have progression and off of it for now. Just wanted to let those interested in it that I found it to be a very easy drug to handle with mild to no side effects.

[Miranda_GO2 Partner in reply to Seaspray298]

Thanks for sharing that with the community. Sorry to hear of your progression, do you and your doctor talk about your next treatment line options?

[Seaspray298 in reply to Miranda_GO2]

I will be having radiation to 2-3 areas starting tomorrow. Dr. spoke of possibly going back on Tecentriq when radiation treatments are completed. I have the KRAS mutation so am anxiously waiting for the new drug that is in trials right now.

[Miranda_GO2 Partner in reply to Seaspray298]

Yes, I am also eagerly looking toward that trial information. Do you know what KRAS mutation you have? Are you part of the peer group for KRAS?

[Seaspray298 in reply to Miranda_GO2]

I have the KRAS G12C mutation. I do not know of any peer groups for KRAS.

[Miranda_GO2 Partner in reply to Seaspray298]

Well, I hope one day we can post about a KRAS approval!

Are you part of the lung cancer registry? If you aren't, please join: healthunlocked.com/api/redi...

The KRAS group is a new group that was started by a patient recently. Here is the link to the page she created: kraskickers.org/. She also has a facebook group. It's not a GO2 group, but I love to connect patients (hints my role as the Phone Buddy manager at GO2) and Terri who started the group is a great person to connect with! I'm sure she would love to meet you (virtually, of course)!

[Denzie Moderator Volunteer in reply to Seaspray298]

Can your doctor get you expanded access for the trial drug or can you get enrolled in the actual trial? And I second everything Miranda said about the KRASkickers group.

[Seaspray298 in reply to Denzie]

My doctor says she hopes to have the trial at Mayo in the Fall. The closest trial to me is 2 hours away which I am not able to do by myself. Today begins my radiation treatments for 10 sessions. Looking forward to getting out of pain!