I read that LDN dose range is between 1.5-10mg

[Demishca]

Hello everyone,

I read somewhere on the LDN research trust website that the range for LDN dose to explore is 1.5-10 mg, is that accurate? Because it contradicts with everything I’ve been learning in the past 4 months...I’m at 4 mg, started at 0.5 mg and I increase 0.5 mg every week and I haven’t figured out my best dose yet, I’ve had MS for 13 years and I currently have an attack affecting my left leg that is now weak and I use a cane to move around...I don’t take any other meds for MS, but I have neuro cardiogenic syncope and I take 0.5 mg Citalopram daily and for good... will the suitable LDN dose fix my leg? I dreamed I was running again around my neighbourhood and I long for that to happen sometime soon....

[Darlingaling]

I have researched that the dose is between 1.5mg and 5mg, with the majority having improvement at 3.5mg. I do know that it HAS to be taken just before bed, no food for 2 hours prior as this inhibits a fast release which is crucial, and must not be made with a filler containing calcium. The calcium can block it and if it bothers you, (anxiety, nightmares, insomnia) take it in the morning for a week or so until you get acclimated to it.

Also, it can take up to a year for some to get a benefit from it.

I took it for 6-8 months before I realized that I didn't have the symptoms or pain that I was used to dealing with. It worked for me but it did take a long time. Stick with it! Hope this helps.

[aredtigress Administrator]

As more doctors prescribe LDN, more is learned. The prevailing thought now is anything below 25 mg is considered Low Dose. This doesn't mean you have to go up that high, but there are some patients that do.

From what I've seen over the years as an admin, MS patients usually end up somewhere between 3mg and 4.5mg. We generally recommend saying at each dose for 4-6 weeks, this allows your body to adjust and for you to start to see benefits.

Benefits can be subtle, some of us stop only to realize it was helping after all. I wish you the best in this journey, and remember - it's a journey not a race

Michelle

[Demishca in reply to aredtigress]

Thank you so much for this, a journey not a race was my mantra today, trying to hold my horses! I guess we all can’t wait to live and live fully and happily...how would you recommend I go about this since I was only staying at each increase for only one week? I was keeping a journal so I kind of have two doses where things were different aka better in some aspects, do you think I should start over? Meaning begin with 0.5 again and stay with that for 4-6 weeks and titrate every 4-6 weeks? Or should I pick up from where I am and revisit the couple of doses that stuck in my head as potential sweet spots and try those only for 4-6 weeks?

[aredtigress Administrator in reply to Demishca]

Personally I wouldn't start over, since you can identify some potential good doses I would go to one of those. Also, as a future FYI, some of us can/will change doses later on - I'm one of those.

I understand you wanting to feel better now - I have Fibromyalgia and at month 3 I called my doctor asking to go off LDN - to try something else. Every issue was flaring and the only good thing happening at that point was my sleep was better. He encouraged me to stick with it another month and month 4 the benefits started.

Michelle

[Demishca in reply to aredtigress]

Thank you Michelle, this is very insightful, this is month 5 for me, i do hear you as I feel my body at least coped with LDN over the months, i used to be a super angry person all the time and constantly in the first 3 months on LDN, very exhausting!

[ratoncita in reply to aredtigress]

How long to feel the best and, what does the best feel like?

[aredtigress Administrator in reply to ratoncita]

The answer will vary person to person. My best seems to be about a 40% reduction in pain including arthritis, gout, and TMJ along with the Fibro. IBS flares are about 50% better and Fibro flares last 3-4 days rather than a week or more.

Many people keep a journal as we adjust rapidly to changes and tend to forget just how much it hurt last week.

Michelle

[ratoncita in reply to aredtigress]

Went to my ND yesterday and we are experimenting with a daytime dose starting with 1.5 for 2 weeks then increasing to 3.0 then perhaps to 4.5. Still,taking 4.5 at bedtime.

[ratoncita in reply to aredtigress]

How about weather related pain? I had a terrible day yesterday; cold and rainy.

[aredtigress Administrator in reply to ratoncita]

The weather will still affect me, but only as long as the nasty weather lasts. It used to send me into a weeks long flare, not anymore. We all respond differently, this seems to happen for a lot of fibro patients. It's not perfect, much better than the past tho!

Michelle

[Demishca]

Do you experience any side effects as in rage or anger with 4.5? I tried a daytime dose but I wasn’t consistent in how I measured it, i would be very curious to know the effect of the daytime dose on you... keep us posted please

[ratoncita]

No anger or rage but I'm not sleeping as well as I used to. Waking at about 3:00 am and trouble going back to sleep. The daytime dose I'm taking is now 4.5.

[Demishca in reply to ratoncita]

I hope the daytime dose is as effective as the night time and that you’re back to normal sleeping routine