Childhood ITP more prone to adult CLL? - ITP Support Assoc...

ITP Support Association

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Childhood ITP more prone to adult CLL?

4 Replies

My oldest daughter had ITP at age 7. After all other treatments failed, the last resort, steroids, cleared her up.

That was 1990. 2020 and now I have CLL/SLL. Coincidence or connection?

Is she more prone to CLL later in life because of childhood ITP?

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4 Replies
Nickie25 profile image
Nickie25

She had childhood ITP and you have CLL, not her? Numerous studies show no connection btw ITP and cancer of any type

Cancer can CAUSE low platelets, but the it is low platelets caused by cancer and not by autoimmune issues.

in reply toNickie25

Thanks for that info, Nickie25!

Marblemaze profile image
Marblemaze

I have CLL/SLL and secondary ITP. ITP is a recognised complication of CLL/SLL. Where ITP occurs, platelets are not falling due to marrow infiltration by lymphocytes, but rather due to immune disregulation. The reason why CLL/SLL can have this effect and cause secondary ITP is not yet entirely understood.

As far as I know there is no known association between childhood idiopathic thrombocytopenia and SLL/CLL (which as you’ll well know is a disease of adults and mostly older adults, although some us get it younger). So your daughter, on my understanding (I’ve read a lot on the subject but I’m no blood doctor), is not more likely to get CLL/SLL because of her childhood ITP.

You probably know that the children of CLL/SLL patients do have a slightly increased risk of CLL/SLL due to the familial link, but this is statistically still a really small risk of my kids getting CLL/SLL, and so I don’t fret about it.

in reply toMarblemaze

Thank you very much for the detailed information!

No, I did not know about the familial link of CLL/SLL.

Until I came to this site, I did not know that some of us also get ITP. I'm on other leukemia sites, too, so I'm surprised that this is my first exposure to this information.

I'm sure glad you're here Doc!

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