Have been tapering off of 120 mg of Prednisone over the last 3 weeks for an asthma exacerbation. It's the highest dose I've ever taken. My last day of 20 mg is tomorrow. I am totally miserable with extreme fatigue, horrible pain all the way up the back of one leg and can hardly walk. Went to ER thinking I had a blood clot. Thankfully, did not. My tongue is so sore, it hurts to eat. Lost appetite and just feel fluish. Hoping this goes away soon after I'm finished, but sounds like the effects could last a long time. It is a miracle drug for breathing, but don't know if I can go through this every time.