I was diagnosed with fibro 7 years ago and only recently have started to go down the APL/APS/Lupus route after seeing a Haem at Sttom. Re the fibro, having tried every medication under the sun so finally the fibro consult at Guys hosp suggested I try pramipexole which did well in clinical trials for fibro pain. I'm wondering has anyone else had experience with this drug? I am struggling with side effects, terrible weight gain, sleep problems (too sleepy or not able to sleep properly) and nausea. I'm at optimal dose now after 14 weeks and am wondering how long I should persist, given that pain reduction has been about 10 percent rather than 30. I'm hoping plaquenil which I am about to start will help me better with pain and fatigue. I'd be grateful to hear of anyone elses experience but realise pramipexole isn't a well known drug for fibro.