These are really interesting posts and I feel for all those who live with terrible gut issues as my daughter does. Please forgive me, but I can't help wondering if focus on ancestry answers the most relevant questions. Many of these posts are from folk hailing from the Midlands and other previously heavily industrialised parts of England. What about environmental indicators particularly from industrial pollutants still lurking in water, soil and therefore food, still impacting people's health and therefore DNA? What about the impacts of mandatory fluoridation of municipal water supply? The legacy from these environmental hazards impacted still further by current urban air pollution have yet to be measured and corrected. Having said all this I am convinced emotional stress plays just as big a role in gut symptoms as genetics and environmental indicators.