It suddenly struck me last night that having a low white blood cell count could cause a masking effect on diagnosing coeliac disease. As it is the B-cells (I think!) that produce antibodies and B-cells are produced by your white blood cells, isn't it the case that if you have a low white blood cell count then your body might not be physically able to turn out the requisite antibodies to register on a blood test? Likewise, couldn't your body be effectively churning out antibodies - at the level your low count permitted - but that might not look like an autoimmune reaction as far as blood tests were concerned - them being calibrated to 'normal' functioning humans with healthy immune systems (over-healthy, arguably)?
It SOUNDS logical to me, but what do I know? Not a lot or I wouldn't be asking this question! Anyone here have the knowledge to know if this is the case, or have any of you heard of a low white blood cell count causing problems in diagnosis, or anything else coeliac-related, for that matter? I'd be thrilled to hear any theories, or better still hard facts if you have them. Thanks!