Can Adaptive Therapy work with BAT

[Rickytarr]

Interesting BAT videos.

youtu.be/Zo4XAoxMm00?featur...(Not working as expected?)

youtu.be/WbhXk-3Wz4s?featur...(Not working as expected?)

Can anyone articulate how adaptive therapy might blend, positively or otherwise with BAT?

Finally, I am sure that anyone interested in BAT who watched the Bryce OlsonRIP video was greatly encouraged by this apparent poster boy for the treatment.

It seemed like he had been extremely fortunate with and perhaps had a few years

More to enjoy with his family.

However, sadly Bryce passed away soon after the video was posted? It was quite a shock. Does anyone know what happened to poor Bryce?

Thanks and best wishes to all.

[PCaWarrior]

Some excellent results for modified BAT programs (fast half-lives or addition of ARPIs or extended cycles using testosterone cypionate).

A CRPC man who was using modified BAT morphed to HSPC. Confirmed.

An HSPC man with a PSA over 900 used modified BAT and his PSA is now 3.

An HSPC man using modified BAT is still HSPC and has used the program for over 14 years.

Two HSPC men using modified BAT has used it more than 2 years with good results.

Another CPRC man using modified BAT appears to be HSPC. Not confirmed.

A CRPC man who used unmodified BAT had very poor results.

A CRPC man using modified BAT had very poor results.

Adaptive therapy can be married to BAT. I have not done it but eventually may need to go that route. So far, modified BAT is working for me.

In the chart, propionate = testosterone propionate. Darolutamide is the ARPI that is used for adaptive therapy.

PSA levels in the chart are examples. I have not used this.

AT+pBAT

[MateoBeach in reply to PCaWarrior]

BAT regimens are intrinsically and "adaptive therapy" application. The devil is in the details. (I am one of the men with long-cycle BAT (3 months high testosterone, then one month ADT with darolutamide). Very successful so far at 2.5 years; PSA undetectable. ARSI is a refinement of protocol to make a cleaner contrast between very high AR signaling and AR blockade to "reset AR sensitivity and impact population dynamics. Russ' pBAT is another refinement over conventional BAT.

[PCaWarrior in reply to MateoBeach]

BAT is adaptive by nature. Even more so if you manage cycle lengths by PSA values.

And even more so if drugs are used in an adaptive fashion.

Even the brute force SOC sequence is adaptive in a sense. If PSA/scans show failure when using hammer A, then goto hammer B... When we run out of hammers, oh well. A lot of effort goes into finding more hammers.

My PSA is going down and recist criteria indicate cancer is stable. But scheduling SBRT for next month. No sense in playing with fire.

[KocoPr]

if PCa is undetectable how can they know where to hit it with SBRT?

Was the site/s detected during your high T phase? What was your PSA during high T?