The Strengths and Weaknesses of BAT, ... - Fight Prostate Ca...

Fight Prostate Cancer

2,956 members1,313 posts

The Strengths and Weaknesses of BAT, interesting article

Farmhand profile image
2 Replies

researchgate.net/publicatio...

Written by
Farmhand profile image
Farmhand
To view profiles and participate in discussions please or .
2 Replies
cesanon profile image
cesanon

"Abstract

It has been shown that when the amount of intracellular androgen receptor in prostate cancer is greatly amplified, such as in the cell line LNCaP 104-R2, then testosterone will stop the growth of those cancer cells. This is the principle behind bipolar androgen therapy, which alternates amplifying intracellular androgen receptors by using very low levels of testosterone with supraphysiologic levels of testosterone. This approach has achieved some limited success in human patients. However, as these cycles continue, some mutations are expected to arise that give the cancer cells a selective growth advantage and lessen the effectiveness of bipolar androgen therapy."

That all makes sense.

Ramp7 profile image
Ramp7

Now if one considers the absolute numerical value of the peaks of the cycles (very low T), cycle length, and throw in a dose of Adaptive Therapy. The outcomes may be more to ones advantage.

Not what you're looking for?

You may also like...

BAT - Current Evidence and Next Steps

"We've been doing a lot of work at Johns Hopkins using high-dose testosterone therapies to...
marnieg46 profile image

Determinants of PSA Response to Bipolar Androgen Therapy [BAT]

New study from Sartor et al below [1]. "Bipolar Androgen Therapy (BAT) is a novel therapy known to...
pjoshea13 profile image

Efficacy and safety of BAT in CRPC following Abi or Enza resistance: A systematic review

New meta-analysis below [1] [2]. Hard to believe that there are enough BAT studies to perform this...
pjoshea13 profile image

My Recent and Temporary BAT failure and it's relation to High Uric Acid (Kidney Stone and Gout)

Hi fellow warriors, I have an update on my BAT n=1 experiment. Above is a graph of my Recent Uric...
KocoPr profile image

? For fellow BATmen on daro and androgen stimulation. Great Article

I came across this 2023 article and i think it poses a great outcome for us who are cycling high T...
KocoPr profile image