Dietary Patterns Are Associated with Risk of Prostate Cancer in a Population-Based Case-Control Study in Montreal, CA - Nutrients -06/27/20

[cujoe]

New Canadian study linking diet and PCa. As with all dietary research, definitely not the final word. Full report compares/contrasts these results with those of other similar studies. In my own view, enough correlations eventually starts to = causation. As with all research, draw your own conclusions.

Dietary Patterns Are Associated with Risk of Prostate Cancer in a Population-Based Case-Control Study in Montreal, Canada

by Karine Trudeau 1,2, Marie-Claude Rousseau 1,2,3, Christine Barul 1, Ilona Csizmadi 4,5 [OrcID] and Marie-Élise Parent 1,2,3,* [OrcID]

1

Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, University of Quebec, Laval, QC H7V 1B7, Canada

2

School of Public Health, Department of Social and Preventive Medicine, University of Montreal, Montreal, QC H3N 1X9, Canada

3

University of Montreal Hospital Research Centre, Montreal, QC H2X 0A9, Canada

4

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA

5

Department of Community Health Sciences, Cumming School of Medicine, Calgary, AB T2N 4N1, Canada

*

Author to whom correspondence should be addressed.

Nutrients 2020, 12(7), 1907; doi.org/10.3390/nu12071907

Received: 4 June 2020 / Revised: 20 June 2020 / Accepted: 25 June 2020 / Published: 27 June 2020

(This article belongs to the Special Issue Nutrition and Prostate Cancer)

Abstract

This study describes the association between dietary patterns and prostate cancer (PCa) risk in a population-based case-control study conducted in Montreal, Canada (2005–2012). Cases (n = 1919) were histologically confirmed, aged ≤75 years. Concomitantly, controls (n = 1991) were randomly selected from the electoral list and frequency-matched to cases by age (±5 years). During face-to-face interviews, a 63-item food frequency questionnaire focusing on the two years before diagnosis/interview was administered. Three dietary patterns were identified from principal component analysis. Unconditional logistic regression estimated the association between dietary patterns and PCa, adjusting for age, ethnicity, education, family history, and timing of last PCa screening. When comparing scores in the highest vs. lowest quartiles, the Healthy Eating pattern was associated with a decreased risk of overall PCa (Odds ratio (OR) = 0.76, 95% confidence interval (CI) = 0.61, 0.93); this association was stronger for high-grade cancers (OR = 0.66, 95% CI = 0.48, 0.89). By contrast, the Western Sweet and Beverages pattern was associated with an elevated risk of overall PCa (OR = 1.35, 95% CI = 1.10, 1.66). The Western Salty and Alcohol pattern was not associated with PCa risk. These findings suggest that some dietary patterns influence PCa development. (emphasis added.)

Full Study is here:

mdpi.com/2072-6643/12/7/190...

Eat Well to Be/Stay Well - K9

[ITCandy]

The study suggests that sugar consumption creates a suitable environment for prostate cancer to grow.

Once you have PCa, does consuming sugar feed the cancer? Something we’ve discussed here for at least a couple of years.

[cujoe in reply to ITCandy]

IT,

I'm not sure you'll get a definitive answer to that question here. Altho' it surely is a legitimate one to ask. I've done a fair amount of research on glycolysis, which is not solely related to sugar consumption. As we quickly come to know when researching sugar metabolism, when we consume refined carbohydrates we might as well be shooting up with simple sugars. And then there is the notorious Warburg effect that comes into play with cancer metabolism. At some point cancer seem to be able to highjack both normal aerobic and anaerobic cell metabolism to support its survival.

Earlier this year, I started to do individual lengthy posts on the "Four Horsemen of the Cancer Apocalypse": gylcolysis, cholesterol, inflammation, and hormone balance (so named by Don Pescado), but decided I was in over my head and was not yet up to doing all the research and self-education needed to do it right, I'll check through my digital files and see if I have any research docs that might help answer your question. (Might take a while for me to get to it.)

Stay Safe - K9

[cujoe in reply to ITCandy]

IT, A quick look came up with these two recent sources of info on glucose levels AFTER diagnosis with PCa. (Got a hurricane headed my way, so i figured I should get this out to you while I can.)

High Blood Sugar and Prostate Cancer

clinicalconnection.hopkinsm...

Blood glucose, glucose balance, and disease-specific survival after prostate cancer diagnosis in the Finnish Randomized Study of Screening for Prostate Cancer

pubmed.ncbi.nlm.nih.gov/306...

A search through the "Similar articles" listing at the pubmed link above might more definitively answer your question. As I've been avoiding added sugars like the plague since my surgery back in 2013, I'm not surprised that the evidence seems to indicate that is the prudent thing to for us all to be doing. We are what we eat - and, if you eat animal products,. as Michael Pollan says, "what we eat eats". Stay Well K9

[ITCandy in reply to cujoe]

It would seem wise to avoid sugar for a number of reasons including possibly encouraging cancer growth.Thanks for your research.

Batten down the hatches and stay safe.

[cujoe in reply to ITCandy]

My pleasure. I keep them that way all year long.

[NPfisherman]

I believe we will find over time that the IF diet may help in treating PCa. A recent article on fasting mimicking diet and breast cancer:

sciencedaily.com/releases/2...

Not as a stand alone, but in conjunction with SOC.....I guess we will have to wait untl they get around to PCa...

Don Pescado

[cujoe in reply to NPfisherman]

NP, I also saw that article on BCa and what they call a "fasting-mimicking diet". As I'm sure you already know, fasting is also one of the ways we can eliminate "zombie" senescent cells that accumulate as we age. Those who follow recent postings by Nalakrats know also of the proliferation of senescent PCa cells due to treatment; i.e., see these 2 studies for more info:

Persistence of senescent prostate cancer cells following prolonged neoadjuvant androgen deprivation therapy

ncbi.nlm.nih.gov/pmc/articl...

Senescent Cells in Cancer Therapy: Friends or Foes?'

sciencedirect.com/science/a...

In addition to fasting and exercise, some drug/supplement combinations help clear senescent cells. The drug/supplement combo most often seen in my reading on the topic is Dasatinib and Quercetin. See this:

Senolytic Treatment with Dasatinib and Quercetin Confirmed to Reduce the Burden of Senescent Cells in Human Patients

fightaging.org/archives/201...

There is much on-going research on fasting and caloric reduction as ways to both fight cancer and increase longevity. As you are frequently know to say, "The Science is coming".

Be Safe & Well, Mon Ami - K9