CRISPR-edited immune cells can survive and thrive after infusion into cancer patients - ScienceDaily - February 6, 2020

[cujoe]

Posted on behalf of a good friend who's fond of saying, "The Science Is Coming":

". . .there is some new science that I think is important"

sciencedaily.com/releases/2...

"The editing of PD-1 out of the T cell is huge--removing the checkpoint to the T cells fight against cancers...YOWZA."

For those of you who may not be familiar with CRISPR, here is a brief description of what it is and how it works:

sciencealert.com/crispr-gen...

And here is a link to the full U Penn research paper in Science:

CRISPR-engineered T cells in patients with refractory cancer

science.sciencemag.org/cont...

Major curative treatment potential for cancer patients down the road. Be Well - Captain K9's gone fishing

[teamkv]

You dig up some great stuff Captain K9!! Thank you!! Pictures of your catch, please....

[cujoe in reply to teamkv]

The thanks for this one goes to the big Fish. I'm sure he will appreciate your comment. Hope you and Kevin are both doing well and having a great start to 2020. Be Well - K9

[NPfisherman]

Thanks for posting this while I was .....ummmm... away...

I have posted my response to your post above this as the real meaning of this should not be lost on anyone... Immune system stimulation will be crucial to eradicate cancer... This technology--CRISPR edited T cells can be combined with what is going on with CAR-T cell development--I think they are on 5th generation of CAR-T development--can a PSMA ligand be added to these CRISPR edited / engineered cells to provide an increase to the attack--They are doing PSMA ligands added to Radiopharmaceuticals and CAR-T...

Could a vaccine be given post infusion as was done in one trial several months ago resulting in a 60% cure rate of a cancer...

The Science is Coming !!! and it gives us....HOPE !!! and it blows me away...

Don Pescado

[NPfisherman]

K9 Caped Crusader,

The ability to remove the T cell receptor and put in a T cell synthetic receptor is huge...Will this make cancer therapy more specific resulting in a more directed attack?? I do believe that is the take home message on the TCR knockout....

Fish

[AlanLawrenson]

All looks very promising, but likely to be EXPENSIVE.