Very interesting even if still not mature: CRISPR editing

[Maxone73]

Zee Germanz got it! A new CRISPR technique.

"These advances enable precise genomic alterations, from single nucleotide changes to the insertion of large DNA segments, potentially transforming the landscape of therapeutic gene editing and opening new possibilities in personalised medicine."

crisprmedicinenews.com/news...

[cujoe]

Max - As you probably already know, last year's sickle call CRISPR "cure" was the blockbuster disease treatment announcement of the year. However, as this news piece announcing that discovery indicates, the cost of it is literally in another financial universe from that most of us lowly PCa patients live:

FDA approves cure for sickle cell disease, the first treatment to use gene-editing tool CRISPR, NBC News, Dec. 8, 2023, 11:19 AM EST / Updated Dec. 8, 2023, 1:19 PM EST

nbcnews.com/health/health-n...

That said, I have seen commentaries stating that, in consideration of the lifetime medical costs for someone with sickle cell, the $2+ mil price-tag is not out of line.

There is also the as-yet-unknown issues related to SEs and secondary diseases brought on by the editing of the genome, not to mention the effects of the pre/post treatment regime. As with all new "breakthrough" treatments, there is much we do not know and widespread access will be a long time coming to the clinic down the street or even the center of excellence a bit farther away.

As always, many thanks for your constant sleuthing (and reporting) on research related to our common disease. Stay S&W, Ciao - cujoe

[Maxone73 in reply to cujoe]

Always like that at the beginning!

[Maxone73 in reply to cujoe]

I have made two calculations....without the monthly exams they make me take, excluding the time that oncologists and nurses have to spend on me monthly, excluding the cost of the monthly Zometa and Decapeptyl (because I don't know their price), excluding the PSMA pet scan every 6 months (again because I don't know that cost)....each of the 6 docetaxel infusions costed 12,000 Eur to the national health system, and Darolutamide 6,000 eur every 4 weeks (in general, not in my case, as I am in a trial it seems), so excluding docetaxel it's 13 x 6,000 that makes 78,000/year for Daro alone...if we try to give some value to what I have excluded above I think I cost around 100,000 Eur per year at least...hopefully I will live for some years, let's make 5 years, it's already half million....I am not sure that an upfront pricey cure would not be better!

Or maybe they are betting against me!!!!!

[NPfisherman]

Max,

Thanks for posting....

As you and I agree, CRISPR is a huge part of the future of medicine with AI... Look for things to change dramatically over the next 10 years as these "tools" get adopted by more researchers, and developments happen...

DD

[Maxone73 in reply to NPfisherman]

If it’s true what the American association of medical doctors said (and not them only) that currently medical knowledge doubles every 72 days (no typo)….interesting times are coming!

[Maxone73 in reply to NPfisherman]

a pearl for you (since you appreciate): technologynetworks.com/biop...

[NPfisherman in reply to Maxone73]

Amazing... improved vision in the blind.... I do appreciate and believe this will play a huge role in medicine...

[swwags]

Hope against hope. CRISPR has to reach economies of scale before it can become a viable treatment option.