PGT-M for BRCA1

[skygreen]

Hi all,

Hope everyone is doing as well as they can be on this crazy IVF rollercoaster.

Just want to see if anyone has any thoughts or has been through a similar situation...

My sister in law has breast cancer and has tested positive for BRCA1 (caught early and doing well thankfully). My husband is awaiting a genetic test so we don't know yet if he has the mutation.

We are due to do a FET with one of the two euploid embryos we have (we did PGT-A due to recurrent failures).

My father in law who carries the gene mutation wants us to consider PGT-M on the embryos. Understandably he is feeling upset and guilty. But it's also not his call.

The dilemma is if it's positive we can't implant. Although there is a raised chance of adult cancer, this might also never happen. My father in law is 72 and cancer free...

Do we test and risk loosing our two precious embryos and the chance of a sibling (this is our last go, we had a successful round 3 years ago). Or are we doing the sensible thing and hopefully they will come back free of the mutation?

Any input would be welcomed!

❤️

[Tamaa]

Hi. This is a tough call. Personally I wouldn't have PGT testing before transfer, specially if it were my last go.But it's a very personal choice (based on faith and hope you could say).

Do you know how bad the mutation actually is?

I have high cancer risks on both sides of my family, though I do not know about any mutation yet.

This is my go-to website:

cancer.gov/about-cancer/cau...

All the best!

[Olive12345]

Have you checked if that’s on the list of genes/diseases they can test for? I wouldn't expect it to be an option in this country. They only screen for serious life limiting genetic diseases.

[skygreen in reply to Olive12345]

Hi,

my clinic in the UK can scan for BRCA1 and BRCA2. I think many do offer it as part of the PGT-M screening. It's amazing what can be done now. But obviously at a cost ❤️