Any live birth success transfering PGT-A aeuploids? Or much better egg quality after high dose ubliquinol?

[islwyn]

I’m 40. I just found out that all of my FIVE day 5 blastocysts came back aeuploid from the PGT-A. Massively disappointed as my FSH was 5.4 to start and Estrogen response was 3 times better than my last retervial when i was 38, even my husband sperm quality has improved. But the result didn’t add up. They are day 6 embyros, slower growth but it end up BB / BB- grades.

Not sure what to do from here on. Dont even know if taking more supplements could make any difference. Anyone experienced mircles?

or has anyone tried transfering aeuploid and resulted in live birth?

thanks for any advice..

[Blueberry211]

Hello, I am so sorry you re going through this. Hugs to you.My clinic refuses to transfer aneuploid embryos and I do understand the reasoning after opting to do PGT A. I think you need to discuss this with your doctor to assess all the risks.

[Mary2022]

I'm sorry to hear that. Unfortunately, aneuploid embryos (abnormal number of chromosomes) are not recommended to transfer by many clinics. I received same bad news last week, my second cycle day 5 blastocyst B (2,2) grade embryo was aneuploid. I followed all the supplements recommended by the book it starts with the egg, very unfortunately it didn't work on me. I think the IVF is kind of lucky draw games...I now move on to the next step.

You should discuss the result with your doctor. Good luck.

[JA-fnuk Partner Nurse Fertility Network UK]

As previous post says maybe you should discuss it with the embryologist so you have the correct information. Also ask clinic what supplements they think would be beneficial for you

Take care

Janet

[Mudra85]

Hi, you might find it hard to find anyone on here who has any experience of transferring known aneuploid embryos as it's not allowed in the UK. First thing that's worth checking is whether any of your 'aneuploid' embryos may have actually been 'mosaic' embryos. Some labs may report mosaics as aneuploids and so it'd be worth clarifying this either with your clinic (ideally a genetic counseller) or directly with the lab that did the testing. If any are mosaic then you should also ask them what percentage of the cells were mosaic, i.e. were they considered to be low or high level mosaics. Mosaics, particularly low level mosaics, can have similar live birth rates as euploids.

Chromosomal abnormalities are unfortunately mostly associated with the egg rather than the sperm and the number of chromosomally abnormal eggs (and therefore embryos) increases with age. I'm not sure there are any supplements which have been proven to make a difference to the number of euploid embryos, but I have heard that the protocol and dose of meds you're on can make a big difference but sadly nothing is guaranteed. It could just be that you had really shoddy luck this cycle and that you will have better fortune in another cycle.

Not sure if any of that helps. Wishing you all the very best!

[islwyn in reply to Mudra85]

thanks. Its good to know its mostly egg issue. I shall look inot improving it. My husband had shingles right before collecting shingles samples. I was wondering if that’s why.

[Mudra85 in reply to islwyn]

It could also be a sperm issue, but from what I understand the vast majority of the time it's believed to be down to the egg. It doesn't mean that sperm can be ruled out as a factor, and if your husband was ill then that could have affected things. It's impossible to say for sure. Probably best to raise it with your consultant at your follow up and see what they say. I hope you're able to find a way forward with things soon, whatever you decide.

[Ivfgotadream]

I agree with other poster to ask if they are actually mosaic rather than full abnormal. I was allowed to transfer a low level mosaic

Also i would reflect on the reasons you decided to PGTA? I pushed clinic to do it after multiple miscarriages but after getting no normals aged 36 decided not to test again and had twins on the next transfer. The science behind PGTA isn’t 100% (probably not want you want to hear I know and I’m sorry) and it was downgraded by the HFEA so I’d consider not testing again and just going for transfer x

[islwyn in reply to Ivfgotadream]

i was actually thinking the same ! Just transfer n not test them