Karyotype testinf

[Core]

Has anyone undergone karyotype testing? After a consultation with a different doctor after all of our failed transfers it was recommended we try this and endometrial biopsy. Has anyone had any experience of this and how much did you pay for the tests? Thanks in advance

[LadyM2019]

Yes I have had a karyotype test. I am an NHS patient but after two failed fresh transfers (1 x 4BA age 33 and 1x 3BB age 34) where I lost my womb lining at 7dp5dt twice, I wanted a second opinion. My NHS consultant said the early heavy bleeding was not a concern and I had bad luck. I povided my treatment history to the private consultant and he said the biggest thing that stood out as a concern was the early bleeding (progesterone issue) but that I should have a karyotype test completed to ensure I did not have a translocation issue. The blood test cost £350 and it took 3 weeks for the results. My results were fine.

I haven't had an endometrial biopsy for NK cell testing or ERA but if my current FET does not work I will be asking for this before any further transfers. I'll need to do it with the private clinic of course as the NHS doesn't offer it,

[Core in reply to LadyM2019]

Good luck with your current FET, what stage are you at? Did just you have the test or your partner also?xx

[Lisichka]

Hi,

I had this test (and a whole bunch of others) done after 4 failed transfers (missed miscarriage, bfn, 2x chemicals). I also did ERA test. Karotype test was fine, cost quite a bit ($400 I think). ERA showed that I need extra 24 hours of progesterone so that was useful. My fifth transfer worked! so I do recommend doing these tests if you’ve had multiple implantation failures. Good luck xxx

[Core in reply to Lisichka]

Congratulations on your pregnancy, that’s really useful to know thanks I think I will be doing them just need to get organised now xx

[Lisichka in reply to Core]

Thank you! Also wanted to add that we did PGS testing too so that played a part in it. But I honestly think that it was ERA that helped.

[Zebedee1971]

We had ours done, was ridiculously expensive, about £400 each... Came back normal, no analysis of results or anything, just 'normal.' when I told my miscarriage specialist we'd done it he told us we shouldn't have, that it was a waste of money. He also told us not to do pgt-a testing but we did it anyway, which resulted in me finding out my two embryos were 'abnormal'... So convinced myself all my eggs were bad. Got pregnant naturally 2 months later and now 7 weeks pregnant. So I put myself under a lot of stress for no reason.

Point is, I trust the opinion of my miscarriage specialist-- he is very upfront about what is worth paying for and what is not. Personally, the karyotype testing for me was the biggest waste of money, and I knew /had a feeling we shouldn't have bothered even as I was getting the bloods done. My specialist said unless you have a history of specific disabilities or disorders in your family, then don't bother.

It's all personal choice in the end

[Core in reply to Zebedee1971]

Congratulations on your pregnancy, how many years had you been ttc if you don’t mind me asking? It’s really useful to hear everyone’s opinions, personally I just want to know I’ve tried everything before moving on to a different route to parenthood xx

[Zebedee1971 in reply to Core]

It will be three years in January. We started trying to conceive January 2018, two very quick early pregnancies, two successive miscarriages first at 7 then at 5 weeks. Then nothing for a year. Three cycles of ivf and no natural pregnancies until three months ago when I got pregnant naturally (chemical) then this pregnancy. Doesn't even feel real to be honest. I'm on steroids so got no symptoms, just very tired. Thing with karyotyping is you literally can't do anything with the results. It won't help you get answers and the chances of it coming back with something is unlikely, most likely it will just come back normal and it will ease your mind. If they identify a genetic abnormality, well, like I said you can't change anything. There are so many tests that are worth doing. This one I'd say is not UNLESS you have family history of genetics issues. Our basic understanding was that if our karyotype test came back abnormal then, what, we give up? Stop trying to have children? After all, if your dna is dodgy, what hope is there? We just weren't ready to consider this as an option, and we were disappointed when we got a piece of paper just saying 'normal' - no analysis, no data, nothing. Just felt like a money making thing to be honest. We ended up getting an answer for our infertility - we found out it was my nk cells attacking the embryos at implantation stage. Best 2k on blood tests I've ever spent as it meant they can give me drugs to keep me pregnant. If I were you, I'd ask: if the karyotype comes back abnormal, what can they do for you? That answer will determine whether you think its worth it I guess.

Like you said, it's good to get different opinions. Some people might say they got help with abnormal results, and that the karyotyping was their 'fix', it just wasn't for me, was just another thing to add to the 'not that then' list. Good luck with whatever you decide to do, it's not easy is it? 😔 X

[Zebedee1971 in reply to Zebedee1971]

Just seen how many bfn you've had. If you haven't looked into nk cell tests, do. (I have amh of 16.5 and always got 15+ eggs at egg collection, never understood why they didn't take). You might have issues with implantation too??

[Core in reply to Zebedee1971]

Thanks, yes I agree with the what do we do if the result was abnormal. We have also been referred to an implantation failure clinic and they will do an endometrial biopsy. My worry was the doctor said 90% of the time the embryo is the issue. This journey is super tough, hope you have a happy and healthy healthy pregnancy xx

[Babyhope8]

I was referred for karyotyping after two miscarriages. My doctor warned me these tests are usually inconclusive . The results came bck normal. I think he was right, these are not worth doing

[Core in reply to Babyhope8]

Thanks for letting me know, I think I am probably less likely to do them now xx

[Ivfgotadream]

My clinic also advised against it - as getting a normal result doesn’t mean that the embryos you make with your partner are going to be “normal”. I’d only do it if there was a suspicion of a genetic disorder in the family

[Core in reply to Ivfgotadream]

Thanks, that’s really useful to hear another doctor’s opinion xx