Endometriosis UK

Zoladex injection - does the day of your cycle matter?

Does it matter when in your cycle you are in terms of receiving the injection? I'm due to see the nurses on Wednesday (2 days away) for the first time and would like to know if they're likely to do the injection or tell me to wait a couple of weeks because my period is due any time in the next 2-5 days. Thank you x

4 Replies

It is better to have it at the beginning of your cycle to avoid a terrible flare (Speaking from experience as well).

I hope it goes well for you and you can enjoy pain free from month two.



Yes if I remember correctly they like to do it around the beginning of your period.


I had mine 2 days after the end of my period and they said that it was fine. I don't rate it at all though as I've still had my period only two weeks after my last and been in constant pain. No one I've spoken to, as of yet, has had a positive experience so just be warned. The actual injection doesn't hurt as much as you might think it will but you do get sore afterwards, in fact the area that got injected is still sore and I'm having my second on Thursday so I don't know when it will wear off.

Best of luck anyway, hope it works for you.

Leya xx


When I had mine no mention of my cycle came up. I have finished a 6 month course now and want to be back on it as all my symptoms have come back. If I remember rightly it was after my second injection that things settled down. For me it was great, the only downside was hot flushes but that was only occasionally. I cannot recommend it enough.


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